Publications

Malumbres, M. (2019). CDK4/6 inhibitors: what is the best cocktail? Clin. Cancer Res25, 6-8. [PMID: 30089874]

Rata, S., Rodriguez, M.F.S.P., Joseph, S., Peter, N., Echegaray-Iturra, F., Yang, F., Madzwamuse, A., Ruppert, J.G., Samejima, K., Platani, M., Álvarez-Fernández, M., Malumbres, M., Earnshaw, W.C., Novak, B. and Hochegger, H. (2018) Two interlinked bistable switches govern mitotic control in mammalian cells. Curr. Biol28, 3824-3832. [PMID: 30449668].

Nguyen, A.L., Drutovic, D., Vázquez, V.N., El Yakoub, W., Gentilello, A.S., Malumbres, M., Solc, P. and Schindler, K. (2018) Genetic interactions between the Aurora kinases reveal new requirements for AURKB and AURKC during oocyte meiosis. Curr. Biol28, 3458-3468.e5. [PMID: 30415701]

Hurtado, B., Trakala, M., Ximénez-Embún, P., El Bakkali, A., Partida, D., Sanz-Castillo, B., Álvarez-Fernández, M., Maroto, M., Sánchez-Martínez, R., Martínez, L., Muñoz, J., García de Frutos, P. & Malumbres, M. (2018) Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets. J. Clin. Invest128, 5351-5367. [PMID: 30252678]

Ovejero, S., Ayala, P., Malumbres, M., Pimentel-Muiños, F.X., Bueno, A. and Sacristán, M.P. (2018) Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1. Sci. Rep8, 11871. [bioRxiv] [PMID: 30089874]

de Cárcer, G.*, Venkateswaran, S.V., Salgueiro, L., El Bakkali, A., Somogyi, K., Rowald, K., Montañes, P., Sanclemente, M., Escobar, B., de Martino, A., McGranahan, N., Malumbres, M.* and Sotillo, R.* (2018).Plk1 overexpression induces chromosomal instability and suppresses tumor development. Nat. Commun., 9, 3012. [*, co-corresponding authors] [BioRxiv] [PMID: 30069007]

Bellutti, F., Tigan, A.S., Nebenfuehr, S., Dolezal, M., Zojer, M., Grausenburger, R., Hartenberger, S., Kollmann, S., Doma, E., Prchal-Murphy, M., Uras, I.Z., Hollein, A., Neuberg, D., Ebert, B.L., Ringler, A., Mueller, A.C., Loizou, J.I., Hinds, P.W., Vogl, C., Heller, G., Kubicek, S., Zuber, J., Malumbres, M., Farlik, M., Villunger, A., Kollmann, K. and Sexl, V. (2018) CDK6 Antoganizes p53-induced responses during tumorigenesis. Cancer Discovery 8, 884-897. [PMID: 30069007]

López-Nieva P., Fernández-Navarro, P., Vaquero-Lorenzo, C., Villa-Morales, M., Graña-Castro, O., Cobos-Fernández, M.Á., López-Lorenzo, J.L., Llamas, P., González-Sanchez, L., Sastre, I., Pollan, M., Malumbres, M., Santos, J. and Fernández-Piqueras, J. (2018) RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas. BMC Cancer 18, 430. [PMID: 29661169]

Mitxelena, J., Apraiz,A., Vallejo-Rodríguez, J., García-Santisteban, I., Fullaondo, A., Alvarez-Fernández, M., Malumbres, M., and Zubiaga, A.M. (2018) An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Nucleic Acids Res46, 4546-4559. [PMID: 29590434]

Álvarez-Fernández, M., Sanz-Flores, M., Sanz-Castillo, B., Salazar-Roa, M., Partida, D., Zapatero-Solana, E., Ali, H.R., Manchado, E., Lowe, S., VanArsdale, T., Shields, D., Caldas, C., Quintela-Fandino, M. and Malumbres, M. (2018) Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer. Cell Death Differ25, 828-840. [PMID: 29229993]

 

Salazar-Roa, M. and Malumbres, M. (2017) Fueling the cell division cycle. Trends Cell Biol. 27, 69-81. [PMID: 27746095]

Esteban-Martínez, L., Sierra-Filardi, E., McGreal, R.S., Salazar-Roa, M., Mariño, G., Seco, E., Durand, S., Enot, D., Graña, O., Malumbres, M., Cvekl, A., Cuervo, A.M., Kroemer, G. and Boya, P. (2017) Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J. 36, 1688-1706. [PMID: 28465321]

Rattani. A., Ballesteros Mejia, R., Roberts, K., Roig, M.B., Godwin, J., Hopkins, M., Eguren, M., Sanchez-Pulido, L., Okaz, E., Ogushi, S., Wolna, M., Metson, J., Pendás, A.M., Malumbres, M., Novák, B., Herbert, M. and Nasmyth, K. (2017) APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity. Curr Biol. 27, 1462-1476. [PMID: 28502659]

Ha, K., Ma, C., Lin, H., Tang, L., Lian, Z., Zhao, F., Li, J.-M., Zhen, B., Pei, H., Han, S., Malumbres, M., Jin, J., Chen, H., Zhao, Y., Zhu, Q. and Zhang, P. (2017) The Anaphase Promoting Complex Impacts Repair Choice by Protecting Ubiquitin Signaling at DNA Damage Sites. Nat Commun. 8, 15751. [PMID: 28604711]

Burgess, A., Vuong, J., Rogers, S., Malumbres, M. and O’Donoghue, S.I. (2017) SnapShot: Phosphoregulation of mitosis. Cell 169, 1358-1358e1. [PMID: 28622516]

de Cárcer, G., Wachowicz, P., Martínez-Martínez, S., Oller, J., Méndez-Barbero, N., Escobar, B.,  González-Loyola, A., Takaki, T., El Bakkali, A., Cámara, J.A., Jiménez-Borreguero, L.J., Bustelo, X., Cañamero, M., Mulero, F., Sevilla, M.d.l.A., Montero, M.J., Redondo, J.M. and Malumbres, M. (2017) Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. Nat. Med. 23, 964-974. [PMID: 28692064]

Quereda, V., Porlan, E., Cañamero, M., Dubus, P. and Malumbres, M. (2016) An essential role for Ink4 and Cip/Kip cell cycle inhibitors in preventing replicative stress. Cell Death Differ. 23, 430-441. [PMID: 26292757]

Correia, N.C., Melão, A., Póvoa, V., Sarmento, L., Gómez de Cedrón, M., Malumbres, M., Enguita, F.J. and Barata, J.T. (2106) microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. Oncotarget 7, 8268-8281. [PMID: 26882564]

Sobecki, M., Mrouj, K., Camasses, A., Parisis, N., Nicolas, E., Llères, D., Gerbe, F., Prieto, S., Krasinska, L., David, A., Eguren, M., Birling, M.-C., Urbach, S., Hem, S., Déjardin, J., Malumbres, M., Jay, P., Dulic, V., Lafontaine, D.L.J., Feil, R.P. and Fisher, D. (2016) The cell proliferation antigen Ki-67 organises heterochromatin. eLife Mar 7;5. pii: e13722. [PMID: 26949251]

Mitxelena, J., Apraiz, A., Vallejo, J., Malumbres, M. and Zubiaga, A. (2016) E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Nucleic Acids Res. 44, 5557-5570. [PMID:   26961310]

Malumbres, M. (2016) CDK4/6 inhibitors resTORe therapeutic sensitivity in HER2+ breast cancer. Cancer Cell 29, 243-244. [PMID: 26977873]

Hydbring, P., Malumbres, M. and Sicinski, P. (2016) Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nat. Rev. Mol. Cell. Biol. 17, 280-292. [PMID: 27033256]

Blas-Rus, N., Bustos-Morán, E., Pérez de Castro, I., de Cárcer, G., Borroto, A., Camafeita, E., Jorge, I., Vázquez J, Alarcón, B., Malumbres, M., Martín-Cófreces, N.B. and Sánchez-Madrid, F. (2016) Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat. Commun. 7, 11389. [PMID: 27091106]

Shao, R., Liu, J., Yan, G., Zhang, J., Han, Y., Guo, J., Xu, Z., Yuan, Z., Liu, J., Malumbres, M., Wan, L., Wei, W. and W. Zou. (2016) Cdh1 Regulates Craniofacial Development via APC-dependent Ubiquitination and Activation of Goosecoid. Cell Res. 26, 699-712 [PMID: 27126000].

Liu, J., Wan, L., Liu, J., Yuan, Z., Zhang, J., Guo, J., Malumbres, M., Liu, J., Zou, W. and Wei, W. (2016) Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discov. 2:15044. [PMID: 27462441]

Scheicher, R., Hoelbl-Kovacic, A., Bellutti, F., Tigan, A.S., Prchal-Murphy, M., Heller, G., Schneckenleithner, C., Salazar-Roa, M., Zoechbauer-Mueller, S., Zuber, J., Malumbres, M., Kollmann, K. and Sexl, V. (2015). CDK6 as a key regulator of hematopoietic and leukemic stem cell activation. Blood 125, 90-101. [PMID: 25342715].

Trakala, M., Rodríguez-Acebes, S., Maroto, M., Symonds, C.E., Santamaría, D., Ortega, S., Barbacid, M., Méndez, J. and Malumbres, M. (2015) Functional reprogramming of polyploidization in megakaryocytes. Dev. Cell 32, 155-167. [PMID: 25625205].

Penas, C., Govek, E.E., Fang, Y., Ramachandran, V., Daniel, M., Wang, W., Maloof, M.E., Rahaim, R.J., Bibian, M., Kawauchi, D., Finkelstein, D., Han, J.L., Long, J., Li, B., Robbins, D.J., Malumbres, M., Roussel, M.F., Roush, W.R., Hatten, M.E. and Ayad, N.G. (2015) Casein Kinase 1δ is an APC/C-Cdh1 substrate that regulates cerebellar granule cell neurogenesis. Cell Reports 11, 249-260. [PMID: 25843713].

Huang, J., Ikeuchi, Y., Malumbres, M. and Bonni, A. (2015) A Cdh1-APC/FMRP ubiquitin signaling link drives mGluR-dependent synaptic plasticity in the mammalian brain. Neuron 86, 726-739. [PMID: 25913861]

Álvarez-Fernández, M. and Malumbres, M. (2015) An atypical oncogene within the atypical E2Fs. J. Natl. Cancer Inst., 107, djv180. [PMID: 26089542]

Trakala, M., Partida, D., Salazar-Roa, M., Maroto, M., Wachowicz, P. de Cárcer, G. and Malumbres, M. (2015). Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice. Blood 126, 1707-1714. [PMID: 26185128]

Serra, H., Chivite, I., Angulo-Urarte, A., Soler, A., Sutherland, J.D., Arruabarrena-Aristorena, A., Ragab, A., Lim, R., Malumbres, M., Fruttiger, M., Potente, M., Serrano, M., Fabra, A., Viñals, F., Casanovas, O., Pandolfi, P.P., Bigas, A., Carracedo, A., Gerhardt, H. and Graupera, M. (2015) PTEN mediates Notch-dependent stalk cell arrest in angiogenesis. Nat. Commun., 6, 7935. [PMID: 26228240]

González-Loyola, A., Fernández-Miranda, G., Trakala, M., Partida, D., Samejima, K., Ogawa, H., Cañamero, M., de Martino, A., Martínez-Ramírez, A., de Cárcer, G., Pérez de Castro, I., Earnshaw, W.C. and Malumbres, M. (2015) Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development. Mol. Cell. Biol. 35, 3566-3578. [PMID: 26240282]

Doménech, E., Maestre, C., Esteban-Martínez, L., Partida, D., Pascual, R., Fernández-Miranda, G., Seco, E., Campos-Olivas, R., Pérez, M., Megias, D., Allen, K., López, M., Saha, A.K., Velasco, G., Rial, E., Méndez, R., Boya, P., Salazar-Roa, M. and Malumbres, M. (2015) AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat. Cell Biol. 17, 1304-1316. [PMID: 26322680]

Sánchez-Martínez, R., Cruz-Gil, S., Gómez de Cedrón, M., Álvarez-Fernández, M., Vargas, T., Molina, S., García, B., Herranz, J., Moreno-Rubio, J., Reglero, G., Pérez-Moreno, M., Feliú, J., Malumbres, M. and Ramírez de Molina, A. (2015) A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy. Oncotarget 6, 38719-38736. [PMID: 26451612]

Esteban-Martínez, L., Doménech, E., Boya, P. Salazar-Roa, M. and Malumbres, M. (2015) Mitophagy in mitosis: more than a myth. Autophagy 11, 2379-2380. [PMID: 26565111]

Malumbres, M. (2015) Keeping order in anaphase. Dev Cell, 35, 403-404. [PMID: 26609955]

Búa, S., Sotiropoulou, P., Sgarlata, C., Borlado, L.R., Eguren, M., Domínguez, O., Ortega, S., Malumbres, M., Blanpain, C. and Méndez, J. (2015) Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle. Cell Cycle 14, 3897-3907. [PMID: 26697840]

Malumbres, M. (2014) Control of the cell cycle. In: Abeloff’s Clinical Oncology, 5th edition. (Niederhuber, J.E., Armitage, J.O., Doroshow, J.H., Kastan, M.B., and Tepper, J.E., eds.) Elsevier, pp. 52-68. [ISBN: 978-1-4557-2865-7]

Trakala, M. and Malumbres, M. (2014) The functional relevance of polyploidization in the skin. Exp. Dermatol. 23, 92-93. [PMID: 24330335]

Eguren, M., Álvarez-Fernández, M., García, F., López-Contreras, A.J., Fujimitsu, K., Yaguchi, H., Luque-García, J.L., Fernández-Capetillo, O., Muñoz, J., Yamano, H. and Malumbres, M. (2014). A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens. Cell Reports 6, 670-683. [PMID: 24508461]

Rattani, A., Vinod, P.K., Godwin, J., Tachibana-Konwalski, K., Wolna, M., Malumbres, M., Novák, B. and Nasmyth, K. (2014). Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible. Curr. Biol. 24, 630-637. [PMID: 24583015]

Wan, L., Tan, M., Yang, J., Inuzuka, H., Dai, X., Wu, T., Liu, J., Shaik, S., Chen, G., Deng, J., Malumbres, M., Letai, A., Kirschner, M.W., Sun, Y. and Wei, W. (2014) APC-Cdc20 suppresses apoptosis through targeting Bim for ubiquitination and destruction. Dev. Cell 29, 377-391. [PMID: 24871945]

de Cárcer, G. and Malumbres, M. (2014) A centrosomal route for cancer genome instability. Nat. Cell Biol. 16, 504-506. [PMID: 24875738]

Álvarez-Fernández, M. and Malumbres, M. (2014) Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry. Bioessays 36, 757-765. [PMID: 24889070]

Wang, P., Malumbres, M. and Archambault, V. (2014) The Greatwall-PP2A Axis in Cell Cycle Control. Methods in Mol. Biol. 1170, 99-111. [PMID: 24906311]

Piazzolla, D., Palla, A.R., Pantoja, C., Cañamero, M., Pérez de Castro, I., Ortega, S., Gómez-López, G., Dominguez, O., Megías, D., Roncador, G., Luque-Garcia, J.L., Fernandez-Tresguerres, B., Fernandez, A.F., Fraga, M.F., Rodriguez-Justo, M., Manzanares, M., Sánchez-Carbayo, M., García-Pedrero, J.M., Rodrigo, J.P., Malumbres, M. and Serrano, M. (2014) Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat. Commun. 5, 4226. [PMID: 24979572]

Malumbres, M. (2014). Cyclin-dependent kinases. Genome Biol. 15, 122. [doi:10.1186/gb4184]

Rodríguez-Díez, E., Quereda, V., Bellutti, F., Prchal-Murphy, M., Partida, D., Eguren, M., Gómez de Cedrón, M., Dubus, P., Cañamero, M., Martínez, L., Sexl, V. and Malumbres, M. (2014) Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis. Blood 124, 2380-2390. [PMID: 25157181]

Malumbres, M. and Pérez de Castro, I. (2014). Aurora kinase A inhibitors: promising agents in anti-tumoral therapy. Expert Opin. Ther. Targets 18, 1377-1393. [PMID: 25200357]

Valcárcel, J. and Malumbres, M. (2014). Splicing together sister chromatids. EMBO J. 33, 2601-2603. [PMID: 25266476]

Trakala, M. and Malumbres, M. (2014). Cyclin C surprises in tumor suppression. Nat. Cell Biol. 16, 1031-1033. [PMID: 25358351]

Parrillas, V., Martínez-Muñoz, L., Holgado, B.L., Kumar, A., Cascio, G., Lucas, P., Rodríguez-Frade, J.M., Malumbres, M., Carrera, A.C., van Wely, K.H., Mellado, M. (2013) Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells. Cell. Mol. Life Sci. 70, 545-558. [PMID: 23001011]

Pick, J.E., Malumbres, M. & Klann, E. (2013) The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice. Learning & Memory 20, 11-20. [PMID: 23242419]

González-Gugel, E., Villa-Morales, M., Santos, J., Bueno, M.J., Malumbres, M., Rodríguez-Pinilla, S.M., Piris, M.A. and Fernández-Piqueras, J. (2013) Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development. Carcinogenesis 34, 902-908. [PMID: 23288923]

Malumbres, M. (2013) miRNAs and cancer: An epigenetics view. Mol. Aspects Med. 34, 863-874. doi: 10.1016/j.mam.2012.06.005 [PMID: 22771542]

Trakala, M., Fernández-Miranda, G., Pérez de Castro, I., Heeschen, C. and Malumbres, M. (2013) Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1. Cell Cycle 12, 1030-1041. [PMID: 23428904]

Doménech, E. and Malumbres, M. (2013) Mitosis-targeting therapies: a troubleshooting guide. Curr. Opin. Pharmacol. 13, 519-528. [PMID: 23583638]

Tuck, C., Zhang, T., Potapova, T., Malumbres, M. and Novák, B. (2013) Robust mitotic entry is ensured by a latching switch. Biol. Open., 2, 924-931. [PMID: 24143279]

Malumbres, M. (2013) Cyclins and Cyclin-dependent kinases. In: Encyclopedia of Systems Biology, (Dubitzky, W., Wolkenhauer, O., Yokota, H. & Cho, K.H., eds.), Springer, Heidelberg, in press. [ISBN 978-1-4419-9864-4]

Malumbres, M. (2013) Mitotic kinases. In: Encyclopedia of Systems Biology (Dubitzky, W., Wolkenhauer, O., Yokota, H. & Cho, K.H., eds), Springer, Heidelberg, in press. [ISBN 978-1-4419-9864-4]

Kim, J.A., Aberg, C., de Cárcer, G., Malumbres, M., Salvati, A. and Dawson, K.A. (2013) Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest. ACS Nano 7, 7483-7494. [PMID: 23941353]

Kollmann, K., Heller, G., Schneckenleithner, C., Warsch, W., Scheicher, R., Ott, R.G., Schäfer, M., Fajmann, S., Schlederer, M., Schiefer, A.-I., Reichart, U., Mayerhofer, M., Hoeller, C., Zöchbauer-Müller, S., Kerjaschki, D., Bock, C., Kenner, L., Hoefler, G., Freissmuth, M., Green, A.R., Moriggl, R., Busslinger, M., Malumbres, M. and Sexl, V. (2013) A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell 24, 167-181. [PMID: 23948297]

Frangini, A., Sjöberg, M., Román-Trufero, M., Dharmalingam, G., Haberle, V., Bartke, T., Lenhard, B.,  Malumbres, M., Vidal, M. and Dillon, N. (2013) The Aurora B kinase and the polycomb protein Ring1B combine to regulate active promoters in quiescent lymphocytes. Mol. Cell 51, 647-661. [PMID:    24034696]

Michel, C.I. and Malumbres, M. (2013) microRNA-203: tumor suppression and beyond. microRNA 2, 118-126. [PMID: 25070781]

Álvarez-Fernández, M., Sánchez-Martínez, R., Sanz-Castillo, B., Gan, P.P., Sanz-Flores, M., Trakala, M., Ruiz-Torres, M., Lorca, T., Castro., A. and Malumbres, M. (2013) Greatwall is essential to prevent mitotic collapse after nuclear envelop breakdown in mammals. Proc. Natl. Acad. Sci. USA. 110, 17374-17379. [PMID: 24101512]

Pérez de Castro, I., Aguirre-Portolés, C., Fernández-Miranda, G., Cañamero, M., Cowley, D.O., van Dyke, T. and Malumbres, M. (2013) Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res. 73, 6804-6815. [PMID: 24242071]

Eguren, M, Porlan, E., Manchado, E., García-Higuera, I., Cañamero, M., Fariñas, I. and Malumbres, M. (2013) The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat. Commun. 4, 2880. doi: 10.1038/ncomms3880. [PMID: 24301385]

 

Manchado, E., Guillamot, M. and Malumbres, M. (2012) Killing cells by targeting mitosis. Cell Death Differ. 19, 369-377. doi: 10.1038/cdd.2011.197 [PMID: 22223105]

Malumbres, M. (2012) miRNAs versus oncogenes: the power of social networking. Mol. Syst. Biol. 8, 569. doi: 10.1038/msb.2012.2 [PMID: 22333973]

Aguirre-Portolés, A., Bird, A.W., Hyman, A., Cañamero, M., Pérez de Castro, I. and Malumbres, M. (2012) Tpx2 controls spindle integrity, genome stability and tumor development. Cancer Res. 72, 1518-1528. [PMID: 22266221]

de Cárcer, G., Pérez de Castro, I. and Malumbres, M. (2012) Inhibiting cell cycle kinases in cancer therapy. Front. Med. Chem. 6, 154-188.

Malumbres, M. (2012) Cell cycle-based therapies move forward. Cancer Cell 22, 419-420. [PMID: 23079651]

Elorza, A., Soro-Arnáiz, I., Meléndez-Rodríguez, F., Rodríguez-Vaello, V., Marsboom, G., de Cárcer, G., Acosta-Iborra, B., Albacete-Albacete, L., Ordóñez, A., Serrano-Oviedo, L., Giménez-Bachs, J.M., Vara-Vega, A., Salinas, A., Sánchez-Prieto, R., Martín del Río, R., Sánchez-Madrid, F., Malumbres, M., Landázuri, M.O., Aragonés, J. (2012) HIF2a acts as an mTORC1 activator through the amino acid carrier SLC7A5. Mol. Cell 48, 681-691. [PMID: 23103253]

Pérez de Castro, I. and Malumbres, M. (2012) Mitotic stress and chromosomal instability in cancer: the case for TPX2. Genes & Cancer 3, 721-730. [PMID: 23634259]

Muñoz, I.G., Yébenes, H., Zhou, M., Mesa, P., Serna, M., Park, A.Y., Bragado-Nilsson, E., Beloso, A., de Cárcer, G., Malumbres, M., Robinson, C.V., Valpuesta, J.M. and Montoya, G. (2011) Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin. Nat. Struct. Mol. Biol. 18, 14-19. [PMID: 21151115]

Song, M.S., Carracedo, A., Salmena, L., Song, S.J., Egia, A., Malumbres, M. and Pandolfi, P.P. (2011) Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144, 187-199. [PMID: 21241890]

de Cárcer, G., Escobar, B., Higuero, A., García, L., Ansón, A., Pérez, G., Mollejo, M., Manning, G., Melendez, B., Abad-Rodriguez, J. and Malumbres, M. (2011) Plk5, a Polo-box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol. Cell. Biol. 31, 1225-1239. [PMID: 21245385]

Kollmann, K., Heller, G., Ott, R.G., Scheicher, R., Zebedin-Brandl, E., Schneckenleithner, C., Simma, O., Warsch, W., Eckelhart, E., Hoelbl, A., Bilban, M., Zöchbauer-Müller, S., Malumbres, M. and Sexl, V. (2011) C-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5’ region of Cdk6. Blood 117, 4065-4075. [PMID: 21300982]

Bueno, M.J. and Malumbres, M. (2011) microRNAs and the cell cycle. Biochim. Biophys. Acta 1812, 592-601. [PMID: 21315819]

Manchado, E. and Malumbres, M. (2011) Targeting aneuploidy for cancer therapy. Cell 144, 465-466. [PMID: 21335229]

Bueno, M.J., Gómez de Cedrón, M., Gómez-López, G., Pérez de Castro, I., di Lisio, L., Montes, S., Martínez, N., Guerrero, M., Sánchez, R., Santos, J., Pisano, D.G., Piris, M.A., Fernández-Piqueras, J. and Malumbres, M. (2011) Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway. Blood 117, 6255-6266. [PMID: 21478429]

Eguren, M., Manchado, E. and Malumbres, M. (2011) Non-mitotic functions of the Anaphase-Promoting Complex. Semin. Cell Dev. Biol. 22, 572-578. [PMID: 21439391]

Chiesa, M.,* Guillamot, M.,* Bueno, M.J. and Malumbres, M. (2011) The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway. Cell Cycle 10, 1607-1617. [PMID: 21502810]

Fernández-Miranda, G., Trakala, M., Martín, J., Escobar, B., González, A., Ghyselinck, N.B., Ortega, S., Cañamero, M., Pérez de Castro, I. and Malumbres, M. (2011) Genetic disruption of Aurora B uncovers an essential role for Aurora C during early mammalian development. Development 138, 2661-2672. [PMID: 21613325]

Malumbres, M. (2011) Oncogene-induced mitotic stress: p53 and pRb get Mad too. Cancer Cell 19, 691-692. [PMID: 21665141]

de Cárcer, G., Manning, G. and Malumbres, M. (2011) From Plk1 to Plk5: functional evolution of Polo-like kinases. Cell Cycle 10, 2255-2262. [PMID: 21654194]

Malumbres, M. (2011) Physiological relevance of cell cycle kinases. Physiol. Rev. 91, 973-1007. [PMID: 21742793]

Santamaría, D. and Malumbres, M. (2011) Tumor suppression by Spinophilin. Cell Cycle 10, 2831-2832. [PMID: 21869595]

Pérez de Castro, I., Aguirre-Portolés, C., Martin, B., Fernández-Miranda, G., Klotzbucher, A., Kubbutat, M.H.G., Megías, D., Arlot-Bonnemains, Y. and Malumbres, M. (2011) A SUMOylation Motif in Aurora-A: Implications in Spindle Dynamics and Oncogenesis. Front. Oncol. 1, 50. [PMID: 22649767]

Wan, L., Zou, W., Gao, D., Inuzuka, Fukushima, H., Berg, A.H., Drapp, R., Shaik, S., Hu, D., Lester, C., Eguren, M., Malumbres, M., Glimcher, L.H. and Wei, W. (2011) Cdh1 Regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol. Cell 44, 721-733. [PMID: 22152476]

Guillamot, M., Manchado, E., Chiesa, M., Gómez-López, G., Pisano, D.G., Sacristán, M. and Malumbres, M. (2011) Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. Sci. Reports 1, 189. DOI:10.1038/srep00189. [PMID: 22355704]

Gurden, M.D.J., Holland, A.J., van Zon, W., Tighe, A., Vergnolle, M.A., Andres, D.A., Spielmann, H.P., Malumbres, M., Wolthuis, R.M.F., Cleveland, D.W. and Taylor, S.S. (2010) Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J. Cell. Sci. 123, 321-330. [PMID: 20053638]

Manchado, E., Eguren, M. and Malumbres, M. (2010) The anaphase promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions. Biochem. Soc. Trans. 38, 65-71. [PMID: 20074037]

Bueno, M.J., Gómez de Cedrón, M., Laresgoiti, U., Fernández-Piqueras, J., Zubiaga, A. and Malumbres, M. (2010) Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signalling. Mol. Cell. Biol. 30, 2983-2995. [PMID: 20404092]

Mourón, S., de Cárcer, G., Seco, E., Fernández-Miranda, G., Malumbres, M. and Nebreda, A.R.  (2010) RINGO/Speedy C is required to sustain the spindle assembly checkpoint. J. Cell Sci. 123, 2586-2595. [PMID: 20605920]

Fernández-Miranda, G., Pérez de Castro, I., Carmena, M., Aguirre-Portolés, C., Ruchaud, S., Fant, X., Montoya, G., Earnshaw, W.C. and Malumbres, M. (2010) Modulation of Aurora B function by SUMOylation. J. Cell Sci. 123, 2823-2833. [PMID: 20663916]

Escobar, B., de Cárcer, G., Fernández-Miranda, G., Cascón, A., Bravo-Cordero, J.J., Montoya, M.C., Robledo, M., Cañamero, M. and Malumbres, M. (2010) Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation. Cancer Res. 70, 9349-9359. [PMID: 20861187].

Santibanez, J.F., Pérez-Gómez, E., Fernandez-L, A., Garrido-Martín, E., Carnero, A., Malumbres, M., Vary, C.P.H., Quintanilla, M. and Bernabéu, C. (2010) The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras. Carcinogenesis 31, 2145-2154. [PMID: 20884686]

Manchado, E., Guillamot, M., de Cárcer, G., Eguren, M., Trickey, M., García-Higuera, I., Moreno, S., Yamano, H., Cañamero, M. and Malumbres, M. (2010) Targeting mitotic exit leads to tumor regression in vivo: modulation by Cdk1, Mastl, and the PP2A/B55a,d phosphatase. Cancer Cell 18, 641-654. [PMID: 21156286]

Quereda, V., and Malumbres, M. (2009) Cell Cycle Control of Pituitary Development and Disease. J. Mol. Endocrinol. 42, 75-86. [PMID: 18987159]

Muñoz, P., Blanco, R., de Carcer, R., Schoeftner, S., Benetti, R., Flores, J.M., Malumbres, M. and Blasco, M.A. (2009) TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol. Cell. Biol. 29, 1608-1625. [PMID: 19124610]

Malumbres, M. and Barbacid, M. (2009) Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev Cancer 9, 153-166. [PMID: 19238148]

Garcia-Lavandeira, M.,  Quereda, V., Flores, I., Saez, C., Diaz-Rodriguez, E., Japon, M.A., Ryan, A.K., Blasco, M.A., Dieguez, C., Malumbres, M.* and Alvarez, C.V.* (2009) A GRFa2/Prop1/Stem (GPS) Cell Niche in the Pituitary. PLoS One 4, e4815. [PMID: 19283075] [* Co-corresponding authors].

Malumbres, M.,* Edward Harlow, Tim Hunt, Tony Hunter, Jill M. Lahti, Gerard Manning, David O. Morgan, Li-Huei Tsai, and Debra J. Wolgemuth (2009) Cyclin-dependent kinases: a family portrait. Nat. Cell Biol. 11, 1275-1276. [PMID: 19884882] [*Corresponding author]

Malumbres, M., Pevarello, P., Barbacid, M. and Bischoff, J.R. (2008) CDK inhibitors in cancer therapy: What is next? Trends Pharmacol Sci. 29, 16-21. [PMID: 18054800]

Bueno, M.J., Pérez de Castro, I., Gómez de Cedrón, M., Santos, J., Calin, G.A., Cigudosa, J.C., Croce, C.M., Fernández-Piqueras, J. and Malumbres, M. (2008) Genetic and Epigenetic Silencing of microRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression. Cancer Cell 13, 496-506. [PMID: 18538733]

García-Higuera, I., Manchado, E., Dubus, P., Cañamero, M., Mendez, J., Moreno, S. and Malumbres, M. (2008) Genomic Stability and Tumor Suppression by the APC/C Cofactor Cdh1. Nat. Cell Biol. 10, 802-811. [PMID: 18552834]

Pérez de Castro, I., de Cárcer, G., Montoya, G. and Malumbres, M. (2008) Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Curr. Opin. Pharmacol. 8, 375-383. [PMID: 18644252]

Bueno, M.J., Pérez de Castro, I. and Malumbres, M. (2008). Control of cell proliferation pathways by microRNAs. Cell Cycle 7, 3143-3148. [PMID: 18843198]

Infante, A., Laresgoiti, U., Fernández-Rueda, J., Fullaondo, A., Galán, J., Díaz-Uriarte, R., Malumbres, M., Field, S.J. and Zubiaga, A.M. (2008) E2F2 Represses Cell Cycle Regulators to Maintain Quiescence. Cell Cycle 7, 3915-3927. [PMID: 19066456]

Malumbres, M. and Barbacid, M. (2007) Cell cycle kinases in cancer. Curr. Opin. Genet. Dev. 17, 60-65.

Pérez de Castro, I., de Cárcer, G. and Malumbres, M. (2007) A census of mitotic cancer genes. New insights into tumor cell biology and cancer therapy. Carcinogenesis 28, 899-912.

de Cárcer, G.; Pérez de Castro, I. and Malumbres, M. (2007) Targeting cell cycle kinases for cancer therapy. Curr. Med. Chem. 14, 969-985.

Cascón, A.,* Escobar, B.,* Montero-Conde, C., Rodríguez-Antona, C., Ruiz-Llorente, S., Osorio, A., Mercadillo, F., Letón, R., de Campos, J.M., García-Sagredo, J.M., Benítez, J., Malumbres, M. and Robledo, M. (2007) Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients. Hum. Mutat. 28, 613-621. [* Co-corresponding authors].

Barrière, C., Santamaría, D., Cerqueira, A., Galán, J., Martín, A., Ortega, S., Malumbres, M., Dubus, P. and Barbacid, M. (2007) Mice thrive without Cdk4 and Cdk2. Mol. Oncol. 1, 72-83.

Quereda, V., Martinalbo, J., Dubus, P., Carnero, A. and Malumbres, M. (2007) Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene 26, 7665-7674.

Malumbres, M. (2007) Cyclin-dependent kinases and their regulators as potential targets for anticancer therapeutics. In: Principles of Molecular Oncology, Bronchud, ed. Humana Press, pp. 204-235.

Santamaría, D., Barrière, C., Cerqueira, A., Hunt, S.L., Tardy, C., Newton, K., Cáceres, J.F., Dubus, P., Malumbres, M. and Barbacid, M. (2007) Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448, 811-815. [PMID: 17700700]

Malumbres, M. (2007) Cyclins and related kinases in cancer cells. J. BUON 12, S45-S52. [PMID: 17935277]

Steitz, J., Büchs, S., Tormo, D., Ferrer, A., Wenzel, J., Huber, C., Wölfel, T., Barbacid, M., Malumbres, M. and Tüting, T. (2006) Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin. Int. J. Cancer 118, 373-380.

Duensing, A., Liu, Y., Tseng, M., Malumbres, M., Barbacid, M. and Duesing, S. (2006) Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene 25, 2943-2949.

Malumbres, M., Dubus, P. and Ortega, S. (2006) Mouse models to study the in vivo function of Cyclin-dependent kinases in normal homeostasis and tumor development. In: Inhibitors of cyclin-dependent kinases as anti-tumor agents (Smith, P.J. and Yue, E.W., eds.) CRC Press, Boca Raton. pp. 55-83.

Malumbres, M. and Barbacid, M. (2006) Is Cyclin D1/Cdk4 kinase a bona-fide cancer target? Cancer Cell 9, 2-4.

Hacker, E., Muller, H.K., Irwin, N., Gabrielli, B., Lincoln, D., Pavey, S., Powell, M.B., Malumbres, M., Barbacid, M., Hayward, N. and Walker, G. (2006) Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Res. 66, 2946-2952.

Malumbres, M. (2006) Therapeutic opportunities to control tumor cell cycles. Clin. Transl. Oncol. 8, 399-408.

Tormo, D., Ferrer, A., Gaffal, E., Wenzel, J., Basner-Tschakarjan, E., Steitz, J., Heukamp, L.C., Gutgemann, I., Buettner, R., Malumbres, M., Barbacid, M., Merlino, G., Tuting, T. (2006). Rapid Growth of Invasive Metastatic Melanoma in Carcinogen-Treated Hepatocyte Growth Factor/Scatter Factor-Transgenic Mice Carrying an Oncogenic CDK4 Mutation. Am. J. Pathol. 169, 665-672.

Blazquez, C., Carracedo, A., Barrado, L., Real, P.J., Fernández-Luna, J.L., Velasco, G., Malumbres, M. and Guzman, M. (2006) Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J. 20, 2633-2635.

Malumbres, M. (2006) Preclinical models for cell cycle-targeted therapies. Adv. Exp. Med. Biol. 587, 139-147.

Malumbres, M. (2005) Revisiting the “Cdk-centric” view of the mammalian cell cycle. Cell Cycle 4, 206-210.

Pérez de Castro, I., Benet, M., Jiménez, M., Alzabin, S., Malumbres, M. and Pellicer, A. (2005) Mouse p10, an alternative spliced form of p15INK4b, inhibits cell cycle progression and malignant transformation. Cancer Res., 65, 3249-3256.

Sotillo, R., Renner, O., Dubus, P., Ruiz-Cabello, J., Martín-Caballero, J., Barbacid, M., Carnero, A. and Malumbres, M. (2005) Cooperation Between Cdk4 and p27Kip1 in Tumor Development: a Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity. Cancer Res., 65, 3846-3852.

Martín, A., Odajima, J., Hunt, S.L., Dubus, P., Ortega, S., Malumbres, M.* and Barbacid, M.* (2005) Cell Cycle Inhibition and Tumor Suppression by p21Cip1 and p27Kip1 are Independent of Cdk2. Cancer Cell 7, 591-598. [*Co-corresponding authors]

Abella, A., Dubus, P., Malumbres, M., Rane, S.G., Kiyokawa, H., Sicard, A., Vignon, F., Langin, D., Barbacid, M. and Fajas, L. (2005) Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metabolism 2, 239-249.

Malumbres, M. and Barbacid, M. (2005) Mammalian cyclin-dependent kinases. Trends Biochem. Sci., 30, 630-641.

Barbacid, M., Ortega, S., Sotillo, R., Odajima, J., Martín, A., Santamaría, D., Dubus, P. and Malumbres, M. (2005) Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases. Cold Spring Harb. Symp. Quant. Biol. 70, 233-240.

2019

Malumbres, M. (2019). CDK4/6 inhibitors: what is the best cocktail? Clin. Cancer Res25, 6-8. [PMID: 30089874]

2018

Rata, S., Rodriguez, M.F.S.P., Joseph, S., Peter, N., Echegaray-Iturra, F., Yang, F., Madzwamuse, A., Ruppert, J.G., Samejima, K., Platani, M., Álvarez-Fernández, M., Malumbres, M., Earnshaw, W.C., Novak, B. and Hochegger, H. (2018) Two interlinked bistable switches govern mitotic control in mammalian cells. Curr. Biol28, 3824-3832. [PMID: 30449668].

Nguyen, A.L., Drutovic, D., Vázquez, V.N., El Yakoub, W., Gentilello, A.S., Malumbres, M., Solc, P. and Schindler, K. (2018) Genetic interactions between the Aurora kinases reveal new requirements for AURKB and AURKC during oocyte meiosis. Curr. Biol28, 3458-3468.e5. [PMID: 30415701]

Hurtado, B., Trakala, M., Ximénez-Embún, P., El Bakkali, A., Partida, D., Sanz-Castillo, B., Álvarez-Fernández, M., Maroto, M., Sánchez-Martínez, R., Martínez, L., Muñoz, J., García de Frutos, P. & Malumbres, M. (2018) Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets. J. Clin. Invest128, 5351-5367. [PMID: 30252678]

Ovejero, S., Ayala, P., Malumbres, M., Pimentel-Muiños, F.X., Bueno, A. and Sacristán, M.P. (2018) Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1. Sci. Rep8, 11871. [bioRxiv] [PMID: 30089874]

de Cárcer, G.*, Venkateswaran, S.V., Salgueiro, L., El Bakkali, A., Somogyi, K., Rowald, K., Montañes, P., Sanclemente, M., Escobar, B., de Martino, A., McGranahan, N., Malumbres, M.* and Sotillo, R.* (2018).Plk1 overexpression induces chromosomal instability and suppresses tumor development. Nat. Commun., 9, 3012. [*, co-corresponding authors] [BioRxiv] [PMID: 30069007]

Bellutti, F., Tigan, A.S., Nebenfuehr, S., Dolezal, M., Zojer, M., Grausenburger, R., Hartenberger, S., Kollmann, S., Doma, E., Prchal-Murphy, M., Uras, I.Z., Hollein, A., Neuberg, D., Ebert, B.L., Ringler, A., Mueller, A.C., Loizou, J.I., Hinds, P.W., Vogl, C., Heller, G., Kubicek, S., Zuber, J., Malumbres, M., Farlik, M., Villunger, A., Kollmann, K. and Sexl, V. (2018) CDK6 Antoganizes p53-induced responses during tumorigenesis. Cancer Discovery 8, 884-897. [PMID: 30069007]

López-Nieva P., Fernández-Navarro, P., Vaquero-Lorenzo, C., Villa-Morales, M., Graña-Castro, O., Cobos-Fernández, M.Á., López-Lorenzo, J.L., Llamas, P., González-Sanchez, L., Sastre, I., Pollan, M., Malumbres, M., Santos, J. and Fernández-Piqueras, J. (2018) RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas. BMC Cancer 18, 430. [PMID: 29661169]

Mitxelena, J., Apraiz,A., Vallejo-Rodríguez, J., García-Santisteban, I., Fullaondo, A., Alvarez-Fernández, M., Malumbres, M., and Zubiaga, A.M. (2018) An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Nucleic Acids Res46, 4546-4559. [PMID: 29590434]

Álvarez-Fernández, M., Sanz-Flores, M., Sanz-Castillo, B., Salazar-Roa, M., Partida, D., Zapatero-Solana, E., Ali, H.R., Manchado, E., Lowe, S., VanArsdale, T., Shields, D., Caldas, C., Quintela-Fandino, M. and Malumbres, M. (2018) Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer. Cell Death Differ25, 828-840. [PMID: 29229993]

 

2017

Salazar-Roa, M. and Malumbres, M. (2017) Fueling the cell division cycle. Trends Cell Biol. 27, 69-81. [PMID: 27746095]

Esteban-Martínez, L., Sierra-Filardi, E., McGreal, R.S., Salazar-Roa, M., Mariño, G., Seco, E., Durand, S., Enot, D., Graña, O., Malumbres, M., Cvekl, A., Cuervo, A.M., Kroemer, G. and Boya, P. (2017) Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J. 36, 1688-1706. [PMID: 28465321]

Rattani. A., Ballesteros Mejia, R., Roberts, K., Roig, M.B., Godwin, J., Hopkins, M., Eguren, M., Sanchez-Pulido, L., Okaz, E., Ogushi, S., Wolna, M., Metson, J., Pendás, A.M., Malumbres, M., Novák, B., Herbert, M. and Nasmyth, K. (2017) APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity. Curr Biol. 27, 1462-1476. [PMID: 28502659]

Ha, K., Ma, C., Lin, H., Tang, L., Lian, Z., Zhao, F., Li, J.-M., Zhen, B., Pei, H., Han, S., Malumbres, M., Jin, J., Chen, H., Zhao, Y., Zhu, Q. and Zhang, P. (2017) The Anaphase Promoting Complex Impacts Repair Choice by Protecting Ubiquitin Signaling at DNA Damage Sites. Nat Commun. 8, 15751. [PMID: 28604711]

Burgess, A., Vuong, J., Rogers, S., Malumbres, M. and O’Donoghue, S.I. (2017) SnapShot: Phosphoregulation of mitosis. Cell 169, 1358-1358e1. [PMID: 28622516]

de Cárcer, G., Wachowicz, P., Martínez-Martínez, S., Oller, J., Méndez-Barbero, N., Escobar, B.,  González-Loyola, A., Takaki, T., El Bakkali, A., Cámara, J.A., Jiménez-Borreguero, L.J., Bustelo, X., Cañamero, M., Mulero, F., Sevilla, M.d.l.A., Montero, M.J., Redondo, J.M. and Malumbres, M. (2017) Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. Nat. Med. 23, 964-974. [PMID: 28692064]

2016

Quereda, V., Porlan, E., Cañamero, M., Dubus, P. and Malumbres, M. (2016) An essential role for Ink4 and Cip/Kip cell cycle inhibitors in preventing replicative stress. Cell Death Differ. 23, 430-441. [PMID: 26292757]

Correia, N.C., Melão, A., Póvoa, V., Sarmento, L., Gómez de Cedrón, M., Malumbres, M., Enguita, F.J. and Barata, J.T. (2106) microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. Oncotarget 7, 8268-8281. [PMID: 26882564]

Sobecki, M., Mrouj, K., Camasses, A., Parisis, N., Nicolas, E., Llères, D., Gerbe, F., Prieto, S., Krasinska, L., David, A., Eguren, M., Birling, M.-C., Urbach, S., Hem, S., Déjardin, J., Malumbres, M., Jay, P., Dulic, V., Lafontaine, D.L.J., Feil, R.P. and Fisher, D. (2016) The cell proliferation antigen Ki-67 organises heterochromatin. eLife Mar 7;5. pii: e13722. [PMID: 26949251]

Mitxelena, J., Apraiz, A., Vallejo, J., Malumbres, M. and Zubiaga, A. (2016) E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Nucleic Acids Res. 44, 5557-5570. [PMID:   26961310]

Malumbres, M. (2016) CDK4/6 inhibitors resTORe therapeutic sensitivity in HER2+ breast cancer. Cancer Cell 29, 243-244. [PMID: 26977873]

Hydbring, P., Malumbres, M. and Sicinski, P. (2016) Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nat. Rev. Mol. Cell. Biol. 17, 280-292. [PMID: 27033256]

Blas-Rus, N., Bustos-Morán, E., Pérez de Castro, I., de Cárcer, G., Borroto, A., Camafeita, E., Jorge, I., Vázquez J, Alarcón, B., Malumbres, M., Martín-Cófreces, N.B. and Sánchez-Madrid, F. (2016) Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat. Commun. 7, 11389. [PMID: 27091106]

Shao, R., Liu, J., Yan, G., Zhang, J., Han, Y., Guo, J., Xu, Z., Yuan, Z., Liu, J., Malumbres, M., Wan, L., Wei, W. and W. Zou. (2016) Cdh1 Regulates Craniofacial Development via APC-dependent Ubiquitination and Activation of Goosecoid. Cell Res. 26, 699-712 [PMID: 27126000].

Liu, J., Wan, L., Liu, J., Yuan, Z., Zhang, J., Guo, J., Malumbres, M., Liu, J., Zou, W. and Wei, W. (2016) Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discov. 2:15044. [PMID: 27462441]

2015

Scheicher, R., Hoelbl-Kovacic, A., Bellutti, F., Tigan, A.S., Prchal-Murphy, M., Heller, G., Schneckenleithner, C., Salazar-Roa, M., Zoechbauer-Mueller, S., Zuber, J., Malumbres, M., Kollmann, K. and Sexl, V. (2015). CDK6 as a key regulator of hematopoietic and leukemic stem cell activation. Blood 125, 90-101. [PMID: 25342715].

Trakala, M., Rodríguez-Acebes, S., Maroto, M., Symonds, C.E., Santamaría, D., Ortega, S., Barbacid, M., Méndez, J. and Malumbres, M. (2015) Functional reprogramming of polyploidization in megakaryocytes. Dev. Cell 32, 155-167. [PMID: 25625205].

Penas, C., Govek, E.E., Fang, Y., Ramachandran, V., Daniel, M., Wang, W., Maloof, M.E., Rahaim, R.J., Bibian, M., Kawauchi, D., Finkelstein, D., Han, J.L., Long, J., Li, B., Robbins, D.J., Malumbres, M., Roussel, M.F., Roush, W.R., Hatten, M.E. and Ayad, N.G. (2015) Casein Kinase 1δ is an APC/C-Cdh1 substrate that regulates cerebellar granule cell neurogenesis. Cell Reports 11, 249-260. [PMID: 25843713].

Huang, J., Ikeuchi, Y., Malumbres, M. and Bonni, A. (2015) A Cdh1-APC/FMRP ubiquitin signaling link drives mGluR-dependent synaptic plasticity in the mammalian brain. Neuron 86, 726-739. [PMID: 25913861]

Álvarez-Fernández, M. and Malumbres, M. (2015) An atypical oncogene within the atypical E2Fs. J. Natl. Cancer Inst., 107, djv180. [PMID: 26089542]

Trakala, M., Partida, D., Salazar-Roa, M., Maroto, M., Wachowicz, P. de Cárcer, G. and Malumbres, M. (2015). Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice. Blood 126, 1707-1714. [PMID: 26185128]

Serra, H., Chivite, I., Angulo-Urarte, A., Soler, A., Sutherland, J.D., Arruabarrena-Aristorena, A., Ragab, A., Lim, R., Malumbres, M., Fruttiger, M., Potente, M., Serrano, M., Fabra, A., Viñals, F., Casanovas, O., Pandolfi, P.P., Bigas, A., Carracedo, A., Gerhardt, H. and Graupera, M. (2015) PTEN mediates Notch-dependent stalk cell arrest in angiogenesis. Nat. Commun., 6, 7935. [PMID: 26228240]

González-Loyola, A., Fernández-Miranda, G., Trakala, M., Partida, D., Samejima, K., Ogawa, H., Cañamero, M., de Martino, A., Martínez-Ramírez, A., de Cárcer, G., Pérez de Castro, I., Earnshaw, W.C. and Malumbres, M. (2015) Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development. Mol. Cell. Biol. 35, 3566-3578. [PMID: 26240282]

Doménech, E., Maestre, C., Esteban-Martínez, L., Partida, D., Pascual, R., Fernández-Miranda, G., Seco, E., Campos-Olivas, R., Pérez, M., Megias, D., Allen, K., López, M., Saha, A.K., Velasco, G., Rial, E., Méndez, R., Boya, P., Salazar-Roa, M. and Malumbres, M. (2015) AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat. Cell Biol. 17, 1304-1316. [PMID: 26322680]

Sánchez-Martínez, R., Cruz-Gil, S., Gómez de Cedrón, M., Álvarez-Fernández, M., Vargas, T., Molina, S., García, B., Herranz, J., Moreno-Rubio, J., Reglero, G., Pérez-Moreno, M., Feliú, J., Malumbres, M. and Ramírez de Molina, A. (2015) A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy. Oncotarget 6, 38719-38736. [PMID: 26451612]

Esteban-Martínez, L., Doménech, E., Boya, P. Salazar-Roa, M. and Malumbres, M. (2015) Mitophagy in mitosis: more than a myth. Autophagy 11, 2379-2380. [PMID: 26565111]

Malumbres, M. (2015) Keeping order in anaphase. Dev Cell, 35, 403-404. [PMID: 26609955]

Búa, S., Sotiropoulou, P., Sgarlata, C., Borlado, L.R., Eguren, M., Domínguez, O., Ortega, S., Malumbres, M., Blanpain, C. and Méndez, J. (2015) Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle. Cell Cycle 14, 3897-3907. [PMID: 26697840]

 

2014

Malumbres, M. (2014) Control of the cell cycle. In: Abeloff’s Clinical Oncology, 5th edition. (Niederhuber, J.E., Armitage, J.O., Doroshow, J.H., Kastan, M.B., and Tepper, J.E., eds.) Elsevier, pp. 52-68. [ISBN: 978-1-4557-2865-7]

Trakala, M. and Malumbres, M. (2014) The functional relevance of polyploidization in the skin. Exp. Dermatol. 23, 92-93. [PMID: 24330335]

Eguren, M., Álvarez-Fernández, M., García, F., López-Contreras, A.J., Fujimitsu, K., Yaguchi, H., Luque-García, J.L., Fernández-Capetillo, O., Muñoz, J., Yamano, H. and Malumbres, M. (2014). A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens. Cell Reports 6, 670-683. [PMID: 24508461]

Rattani, A., Vinod, P.K., Godwin, J., Tachibana-Konwalski, K., Wolna, M., Malumbres, M., Novák, B. and Nasmyth, K. (2014). Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible. Curr. Biol. 24, 630-637. [PMID: 24583015]

Wan, L., Tan, M., Yang, J., Inuzuka, H., Dai, X., Wu, T., Liu, J., Shaik, S., Chen, G., Deng, J., Malumbres, M., Letai, A., Kirschner, M.W., Sun, Y. and Wei, W. (2014) APC-Cdc20 suppresses apoptosis through targeting Bim for ubiquitination and destruction. Dev. Cell 29, 377-391. [PMID: 24871945]

de Cárcer, G. and Malumbres, M. (2014) A centrosomal route for cancer genome instability. Nat. Cell Biol. 16, 504-506. [PMID: 24875738]

Álvarez-Fernández, M. and Malumbres, M. (2014) Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry. Bioessays 36, 757-765. [PMID: 24889070]

Wang, P., Malumbres, M. and Archambault, V. (2014) The Greatwall-PP2A Axis in Cell Cycle Control. Methods in Mol. Biol. 1170, 99-111. [PMID: 24906311]

Piazzolla, D., Palla, A.R., Pantoja, C., Cañamero, M., Pérez de Castro, I., Ortega, S., Gómez-López, G., Dominguez, O., Megías, D., Roncador, G., Luque-Garcia, J.L., Fernandez-Tresguerres, B., Fernandez, A.F., Fraga, M.F., Rodriguez-Justo, M., Manzanares, M., Sánchez-Carbayo, M., García-Pedrero, J.M., Rodrigo, J.P., Malumbres, M. and Serrano, M. (2014) Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat. Commun. 5, 4226. [PMID: 24979572]

Malumbres, M. (2014). Cyclin-dependent kinases. Genome Biol. 15, 122. [doi:10.1186/gb4184]

Rodríguez-Díez, E., Quereda, V., Bellutti, F., Prchal-Murphy, M., Partida, D., Eguren, M., Gómez de Cedrón, M., Dubus, P., Cañamero, M., Martínez, L., Sexl, V. and Malumbres, M. (2014) Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis. Blood 124, 2380-2390. [PMID: 25157181]

Malumbres, M. and Pérez de Castro, I. (2014). Aurora kinase A inhibitors: promising agents in anti-tumoral therapy. Expert Opin. Ther. Targets 18, 1377-1393. [PMID: 25200357]

Valcárcel, J. and Malumbres, M. (2014). Splicing together sister chromatids. EMBO J. 33, 2601-2603. [PMID: 25266476]

Trakala, M. and Malumbres, M. (2014). Cyclin C surprises in tumor suppression. Nat. Cell Biol. 16, 1031-1033. [PMID: 25358351]

2013

Parrillas, V., Martínez-Muñoz, L., Holgado, B.L., Kumar, A., Cascio, G., Lucas, P., Rodríguez-Frade, J.M., Malumbres, M., Carrera, A.C., van Wely, K.H., Mellado, M. (2013) Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells. Cell. Mol. Life Sci. 70, 545-558. [PMID: 23001011]

Pick, J.E., Malumbres, M. & Klann, E. (2013) The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice. Learning & Memory 20, 11-20. [PMID: 23242419]

González-Gugel, E., Villa-Morales, M., Santos, J., Bueno, M.J., Malumbres, M., Rodríguez-Pinilla, S.M., Piris, M.A. and Fernández-Piqueras, J. (2013) Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development. Carcinogenesis 34, 902-908. [PMID: 23288923]

Malumbres, M. (2013) miRNAs and cancer: An epigenetics view. Mol. Aspects Med. 34, 863-874. doi: 10.1016/j.mam.2012.06.005 [PMID: 22771542]

Trakala, M., Fernández-Miranda, G., Pérez de Castro, I., Heeschen, C. and Malumbres, M. (2013) Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1. Cell Cycle 12, 1030-1041. [PMID: 23428904]

Doménech, E. and Malumbres, M. (2013) Mitosis-targeting therapies: a troubleshooting guide. Curr. Opin. Pharmacol. 13, 519-528. [PMID: 23583638]

Tuck, C., Zhang, T., Potapova, T., Malumbres, M. and Novák, B. (2013) Robust mitotic entry is ensured by a latching switch. Biol. Open., 2, 924-931. [PMID: 24143279]

Malumbres, M. (2013) Cyclins and Cyclin-dependent kinases. In: Encyclopedia of Systems Biology, (Dubitzky, W., Wolkenhauer, O., Yokota, H. & Cho, K.H., eds.), Springer, Heidelberg, in press. [ISBN 978-1-4419-9864-4]

Malumbres, M. (2013) Mitotic kinases. In: Encyclopedia of Systems Biology (Dubitzky, W., Wolkenhauer, O., Yokota, H. & Cho, K.H., eds), Springer, Heidelberg, in press. [ISBN 978-1-4419-9864-4]

Kim, J.A., Aberg, C., de Cárcer, G., Malumbres, M., Salvati, A. and Dawson, K.A. (2013) Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest. ACS Nano 7, 7483-7494. [PMID: 23941353]

Kollmann, K., Heller, G., Schneckenleithner, C., Warsch, W., Scheicher, R., Ott, R.G., Schäfer, M., Fajmann, S., Schlederer, M., Schiefer, A.-I., Reichart, U., Mayerhofer, M., Hoeller, C., Zöchbauer-Müller, S., Kerjaschki, D., Bock, C., Kenner, L., Hoefler, G., Freissmuth, M., Green, A.R., Moriggl, R., Busslinger, M., Malumbres, M. and Sexl, V. (2013) A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell 24, 167-181. [PMID: 23948297]

Frangini, A., Sjöberg, M., Román-Trufero, M., Dharmalingam, G., Haberle, V., Bartke, T., Lenhard, B.,  Malumbres, M., Vidal, M. and Dillon, N. (2013) The Aurora B kinase and the polycomb protein Ring1B combine to regulate active promoters in quiescent lymphocytes. Mol. Cell 51, 647-661. [PMID:    24034696]

Michel, C.I. and Malumbres, M. (2013) microRNA-203: tumor suppression and beyond. microRNA 2, 118-126. [PMID: 25070781]

Álvarez-Fernández, M., Sánchez-Martínez, R., Sanz-Castillo, B., Gan, P.P., Sanz-Flores, M., Trakala, M., Ruiz-Torres, M., Lorca, T., Castro., A. and Malumbres, M. (2013) Greatwall is essential to prevent mitotic collapse after nuclear envelop breakdown in mammals. Proc. Natl. Acad. Sci. USA. 110, 17374-17379. [PMID: 24101512]

Pérez de Castro, I., Aguirre-Portolés, C., Fernández-Miranda, G., Cañamero, M., Cowley, D.O., van Dyke, T. and Malumbres, M. (2013) Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res. 73, 6804-6815. [PMID: 24242071]

Eguren, M, Porlan, E., Manchado, E., García-Higuera, I., Cañamero, M., Fariñas, I. and Malumbres, M. (2013) The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat. Commun. 4, 2880. doi: 10.1038/ncomms3880. [PMID: 24301385]

 

2012

Manchado, E., Guillamot, M. and Malumbres, M. (2012) Killing cells by targeting mitosis. Cell Death Differ. 19, 369-377. doi: 10.1038/cdd.2011.197 [PMID: 22223105]

Malumbres, M. (2012) miRNAs versus oncogenes: the power of social networking. Mol. Syst. Biol. 8, 569. doi: 10.1038/msb.2012.2 [PMID: 22333973]

Aguirre-Portolés, A., Bird, A.W., Hyman, A., Cañamero, M., Pérez de Castro, I. and Malumbres, M. (2012) Tpx2 controls spindle integrity, genome stability and tumor development. Cancer Res. 72, 1518-1528. [PMID: 22266221]

de Cárcer, G., Pérez de Castro, I. and Malumbres, M. (2012) Inhibiting cell cycle kinases in cancer therapy. Front. Med. Chem. 6, 154-188.

Malumbres, M. (2012) Cell cycle-based therapies move forward. Cancer Cell 22, 419-420. [PMID: 23079651]

Elorza, A., Soro-Arnáiz, I., Meléndez-Rodríguez, F., Rodríguez-Vaello, V., Marsboom, G., de Cárcer, G., Acosta-Iborra, B., Albacete-Albacete, L., Ordóñez, A., Serrano-Oviedo, L., Giménez-Bachs, J.M., Vara-Vega, A., Salinas, A., Sánchez-Prieto, R., Martín del Río, R., Sánchez-Madrid, F., Malumbres, M., Landázuri, M.O., Aragonés, J. (2012) HIF2a acts as an mTORC1 activator through the amino acid carrier SLC7A5. Mol. Cell 48, 681-691. [PMID: 23103253]

Pérez de Castro, I. and Malumbres, M. (2012) Mitotic stress and chromosomal instability in cancer: the case for TPX2. Genes & Cancer 3, 721-730. [PMID: 23634259]

2011

Muñoz, I.G., Yébenes, H., Zhou, M., Mesa, P., Serna, M., Park, A.Y., Bragado-Nilsson, E., Beloso, A., de Cárcer, G., Malumbres, M., Robinson, C.V., Valpuesta, J.M. and Montoya, G. (2011) Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin. Nat. Struct. Mol. Biol. 18, 14-19. [PMID: 21151115]

Song, M.S., Carracedo, A., Salmena, L., Song, S.J., Egia, A., Malumbres, M. and Pandolfi, P.P. (2011) Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144, 187-199. [PMID: 21241890]

de Cárcer, G., Escobar, B., Higuero, A., García, L., Ansón, A., Pérez, G., Mollejo, M., Manning, G., Melendez, B., Abad-Rodriguez, J. and Malumbres, M. (2011) Plk5, a Polo-box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol. Cell. Biol. 31, 1225-1239. [PMID: 21245385]

Kollmann, K., Heller, G., Ott, R.G., Scheicher, R., Zebedin-Brandl, E., Schneckenleithner, C., Simma, O., Warsch, W., Eckelhart, E., Hoelbl, A., Bilban, M., Zöchbauer-Müller, S., Malumbres, M. and Sexl, V. (2011) C-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5’ region of Cdk6. Blood 117, 4065-4075. [PMID: 21300982]

Bueno, M.J. and Malumbres, M. (2011) microRNAs and the cell cycle. Biochim. Biophys. Acta 1812, 592-601. [PMID: 21315819]

Manchado, E. and Malumbres, M. (2011) Targeting aneuploidy for cancer therapy. Cell 144, 465-466. [PMID: 21335229]

Bueno, M.J., Gómez de Cedrón, M., Gómez-López, G., Pérez de Castro, I., di Lisio, L., Montes, S., Martínez, N., Guerrero, M., Sánchez, R., Santos, J., Pisano, D.G., Piris, M.A., Fernández-Piqueras, J. and Malumbres, M. (2011) Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway. Blood 117, 6255-6266. [PMID: 21478429]

Eguren, M., Manchado, E. and Malumbres, M. (2011) Non-mitotic functions of the Anaphase-Promoting Complex. Semin. Cell Dev. Biol. 22, 572-578. [PMID: 21439391]

Chiesa, M.,* Guillamot, M.,* Bueno, M.J. and Malumbres, M. (2011) The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway. Cell Cycle 10, 1607-1617. [PMID: 21502810]

Fernández-Miranda, G., Trakala, M., Martín, J., Escobar, B., González, A., Ghyselinck, N.B., Ortega, S., Cañamero, M., Pérez de Castro, I. and Malumbres, M. (2011) Genetic disruption of Aurora B uncovers an essential role for Aurora C during early mammalian development. Development 138, 2661-2672. [PMID: 21613325]

Malumbres, M. (2011) Oncogene-induced mitotic stress: p53 and pRb get Mad too. Cancer Cell 19, 691-692. [PMID: 21665141]

de Cárcer, G., Manning, G. and Malumbres, M. (2011) From Plk1 to Plk5: functional evolution of Polo-like kinases. Cell Cycle 10, 2255-2262. [PMID: 21654194]

Malumbres, M. (2011) Physiological relevance of cell cycle kinases. Physiol. Rev. 91, 973-1007. [PMID: 21742793]

Santamaría, D. and Malumbres, M. (2011) Tumor suppression by Spinophilin. Cell Cycle 10, 2831-2832. [PMID: 21869595]

Pérez de Castro, I., Aguirre-Portolés, C., Martin, B., Fernández-Miranda, G., Klotzbucher, A., Kubbutat, M.H.G., Megías, D., Arlot-Bonnemains, Y. and Malumbres, M. (2011) A SUMOylation Motif in Aurora-A: Implications in Spindle Dynamics and Oncogenesis. Front. Oncol. 1, 50. [PMID: 22649767]

Wan, L., Zou, W., Gao, D., Inuzuka, Fukushima, H., Berg, A.H., Drapp, R., Shaik, S., Hu, D., Lester, C., Eguren, M., Malumbres, M., Glimcher, L.H. and Wei, W. (2011) Cdh1 Regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol. Cell 44, 721-733. [PMID: 22152476]

Guillamot, M., Manchado, E., Chiesa, M., Gómez-López, G., Pisano, D.G., Sacristán, M. and Malumbres, M. (2011) Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. Sci. Reports 1, 189. DOI:10.1038/srep00189. [PMID: 22355704]

 

2010

Gurden, M.D.J., Holland, A.J., van Zon, W., Tighe, A., Vergnolle, M.A., Andres, D.A., Spielmann, H.P., Malumbres, M., Wolthuis, R.M.F., Cleveland, D.W. and Taylor, S.S. (2010) Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J. Cell. Sci. 123, 321-330. [PMID: 20053638]

Manchado, E., Eguren, M. and Malumbres, M. (2010) The anaphase promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions. Biochem. Soc. Trans. 38, 65-71. [PMID: 20074037]

Bueno, M.J., Gómez de Cedrón, M., Laresgoiti, U., Fernández-Piqueras, J., Zubiaga, A. and Malumbres, M. (2010) Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signalling. Mol. Cell. Biol. 30, 2983-2995. [PMID: 20404092]

Mourón, S., de Cárcer, G., Seco, E., Fernández-Miranda, G., Malumbres, M. and Nebreda, A.R.  (2010) RINGO/Speedy C is required to sustain the spindle assembly checkpoint. J. Cell Sci. 123, 2586-2595. [PMID: 20605920]

Fernández-Miranda, G., Pérez de Castro, I., Carmena, M., Aguirre-Portolés, C., Ruchaud, S., Fant, X., Montoya, G., Earnshaw, W.C. and Malumbres, M. (2010) Modulation of Aurora B function by SUMOylation. J. Cell Sci. 123, 2823-2833. [PMID: 20663916]

Escobar, B., de Cárcer, G., Fernández-Miranda, G., Cascón, A., Bravo-Cordero, J.J., Montoya, M.C., Robledo, M., Cañamero, M. and Malumbres, M. (2010) Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation. Cancer Res. 70, 9349-9359. [PMID: 20861187].

Santibanez, J.F., Pérez-Gómez, E., Fernandez-L, A., Garrido-Martín, E., Carnero, A., Malumbres, M., Vary, C.P.H., Quintanilla, M. and Bernabéu, C. (2010) The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras. Carcinogenesis 31, 2145-2154. [PMID: 20884686]

Manchado, E., Guillamot, M., de Cárcer, G., Eguren, M., Trickey, M., García-Higuera, I., Moreno, S., Yamano, H., Cañamero, M. and Malumbres, M. (2010) Targeting mitotic exit leads to tumor regression in vivo: modulation by Cdk1, Mastl, and the PP2A/B55a,d phosphatase. Cancer Cell 18, 641-654. [PMID: 21156286]

2009

Quereda, V., and Malumbres, M. (2009) Cell Cycle Control of Pituitary Development and Disease. J. Mol. Endocrinol. 42, 75-86. [PMID: 18987159]

Muñoz, P., Blanco, R., de Carcer, R., Schoeftner, S., Benetti, R., Flores, J.M., Malumbres, M. and Blasco, M.A. (2009) TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol. Cell. Biol. 29, 1608-1625. [PMID: 19124610]

Malumbres, M. and Barbacid, M. (2009) Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev Cancer 9, 153-166. [PMID: 19238148]

Garcia-Lavandeira, M.,  Quereda, V., Flores, I., Saez, C., Diaz-Rodriguez, E., Japon, M.A., Ryan, A.K., Blasco, M.A., Dieguez, C., Malumbres, M.* and Alvarez, C.V.* (2009) A GRFa2/Prop1/Stem (GPS) Cell Niche in the Pituitary. PLoS One 4, e4815. [PMID: 19283075] [* Co-corresponding authors].

Malumbres, M.,* Edward Harlow, Tim Hunt, Tony Hunter, Jill M. Lahti, Gerard Manning, David O. Morgan, Li-Huei Tsai, and Debra J. Wolgemuth (2009) Cyclin-dependent kinases: a family portrait. Nat. Cell Biol. 11, 1275-1276. [PMID: 19884882] [*Corresponding author]

2008

Malumbres, M., Pevarello, P., Barbacid, M. and Bischoff, J.R. (2008) CDK inhibitors in cancer therapy: What is next? Trends Pharmacol Sci. 29, 16-21. [PMID: 18054800]

Bueno, M.J., Pérez de Castro, I., Gómez de Cedrón, M., Santos, J., Calin, G.A., Cigudosa, J.C., Croce, C.M., Fernández-Piqueras, J. and Malumbres, M. (2008) Genetic and Epigenetic Silencing of microRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression. Cancer Cell 13, 496-506. [PMID: 18538733]

García-Higuera, I., Manchado, E., Dubus, P., Cañamero, M., Mendez, J., Moreno, S. and Malumbres, M. (2008) Genomic Stability and Tumor Suppression by the APC/C Cofactor Cdh1. Nat. Cell Biol. 10, 802-811. [PMID: 18552834]

Pérez de Castro, I., de Cárcer, G., Montoya, G. and Malumbres, M. (2008) Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Curr. Opin. Pharmacol. 8, 375-383. [PMID: 18644252]

Bueno, M.J., Pérez de Castro, I. and Malumbres, M. (2008). Control of cell proliferation pathways by microRNAs. Cell Cycle 7, 3143-3148. [PMID: 18843198]

Infante, A., Laresgoiti, U., Fernández-Rueda, J., Fullaondo, A., Galán, J., Díaz-Uriarte, R., Malumbres, M., Field, S.J. and Zubiaga, A.M. (2008) E2F2 Represses Cell Cycle Regulators to Maintain Quiescence. Cell Cycle 7, 3915-3927. [PMID: 19066456]

2007

Malumbres, M. and Barbacid, M. (2007) Cell cycle kinases in cancer. Curr. Opin. Genet. Dev. 17, 60-65.

Pérez de Castro, I., de Cárcer, G. and Malumbres, M. (2007) A census of mitotic cancer genes. New insights into tumor cell biology and cancer therapy. Carcinogenesis 28, 899-912.

de Cárcer, G.; Pérez de Castro, I. and Malumbres, M. (2007) Targeting cell cycle kinases for cancer therapy. Curr. Med. Chem. 14, 969-985.

Cascón, A.,* Escobar, B.,* Montero-Conde, C., Rodríguez-Antona, C., Ruiz-Llorente, S., Osorio, A., Mercadillo, F., Letón, R., de Campos, J.M., García-Sagredo, J.M., Benítez, J., Malumbres, M. and Robledo, M. (2007) Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients. Hum. Mutat. 28, 613-621. [* Co-corresponding authors].

Barrière, C., Santamaría, D., Cerqueira, A., Galán, J., Martín, A., Ortega, S., Malumbres, M., Dubus, P. and Barbacid, M. (2007) Mice thrive without Cdk4 and Cdk2. Mol. Oncol. 1, 72-83.

Quereda, V., Martinalbo, J., Dubus, P., Carnero, A. and Malumbres, M. (2007) Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene 26, 7665-7674.

Malumbres, M. (2007) Cyclin-dependent kinases and their regulators as potential targets for anticancer therapeutics. In: Principles of Molecular Oncology, Bronchud, ed. Humana Press, pp. 204-235.

Santamaría, D., Barrière, C., Cerqueira, A., Hunt, S.L., Tardy, C., Newton, K., Cáceres, J.F., Dubus, P., Malumbres, M. and Barbacid, M. (2007) Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448, 811-815. [PMID: 17700700]

Malumbres, M. (2007) Cyclins and related kinases in cancer cells. J. BUON 12, S45-S52. [PMID: 17935277]

2006

Steitz, J., Büchs, S., Tormo, D., Ferrer, A., Wenzel, J., Huber, C., Wölfel, T., Barbacid, M., Malumbres, M. and Tüting, T. (2006) Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin. Int. J. Cancer 118, 373-380.

Duensing, A., Liu, Y., Tseng, M., Malumbres, M., Barbacid, M. and Duesing, S. (2006) Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene 25, 2943-2949.

Malumbres, M., Dubus, P. and Ortega, S. (2006) Mouse models to study the in vivo function of Cyclin-dependent kinases in normal homeostasis and tumor development. In: Inhibitors of cyclin-dependent kinases as anti-tumor agents (Smith, P.J. and Yue, E.W., eds.) CRC Press, Boca Raton. pp. 55-83.

Malumbres, M. and Barbacid, M. (2006) Is Cyclin D1/Cdk4 kinase a bona-fide cancer target? Cancer Cell 9, 2-4.

Hacker, E., Muller, H.K., Irwin, N., Gabrielli, B., Lincoln, D., Pavey, S., Powell, M.B., Malumbres, M., Barbacid, M., Hayward, N. and Walker, G. (2006) Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Res. 66, 2946-2952.

Malumbres, M. (2006) Therapeutic opportunities to control tumor cell cycles. Clin. Transl. Oncol. 8, 399-408.

Tormo, D., Ferrer, A., Gaffal, E., Wenzel, J., Basner-Tschakarjan, E., Steitz, J., Heukamp, L.C., Gutgemann, I., Buettner, R., Malumbres, M., Barbacid, M., Merlino, G., Tuting, T. (2006). Rapid Growth of Invasive Metastatic Melanoma in Carcinogen-Treated Hepatocyte Growth Factor/Scatter Factor-Transgenic Mice Carrying an Oncogenic CDK4 Mutation. Am. J. Pathol. 169, 665-672.

Blazquez, C., Carracedo, A., Barrado, L., Real, P.J., Fernández-Luna, J.L., Velasco, G., Malumbres, M. and Guzman, M. (2006) Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J. 20, 2633-2635.

Malumbres, M. (2006) Preclinical models for cell cycle-targeted therapies. Adv. Exp. Med. Biol. 587, 139-147.

2005

Malumbres, M. (2005) Revisiting the “Cdk-centric” view of the mammalian cell cycle. Cell Cycle 4, 206-210.

Pérez de Castro, I., Benet, M., Jiménez, M., Alzabin, S., Malumbres, M. and Pellicer, A. (2005) Mouse p10, an alternative spliced form of p15INK4b, inhibits cell cycle progression and malignant transformation. Cancer Res., 65, 3249-3256.

Sotillo, R., Renner, O., Dubus, P., Ruiz-Cabello, J., Martín-Caballero, J., Barbacid, M., Carnero, A. and Malumbres, M. (2005) Cooperation Between Cdk4 and p27Kip1 in Tumor Development: a Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity. Cancer Res., 65, 3846-3852.

Martín, A., Odajima, J., Hunt, S.L., Dubus, P., Ortega, S., Malumbres, M.* and Barbacid, M.* (2005) Cell Cycle Inhibition and Tumor Suppression by p21Cip1 and p27Kip1 are Independent of Cdk2. Cancer Cell 7, 591-598. [*Co-corresponding authors]

Abella, A., Dubus, P., Malumbres, M., Rane, S.G., Kiyokawa, H., Sicard, A., Vignon, F., Langin, D., Barbacid, M. and Fajas, L. (2005) Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metabolism 2, 239-249.

Malumbres, M. and Barbacid, M. (2005) Mammalian cyclin-dependent kinases. Trends Biochem. Sci., 30, 630-641.

Barbacid, M., Ortega, S., Sotillo, R., Odajima, J., Martín, A., Santamaría, D., Dubus, P. and Malumbres, M. (2005) Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases. Cold Spring Harb. Symp. Quant. Biol. 70, 233-240.

Doctoral Thesis

Covers