Publications

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List of publications per year

Bustos-Morán, E., Blas-Rus, N., Alcaraz-Serna, A., Iborra, S., González-Martínez, J., Malumbres, M., Sánchez-Madrid, F. (2019) Aurora A controls CD8+ T cell cytotoxic activity and antiviral response. Sci Rep. 9, 2211. [PMID:30778113][Full text]

Vázquez-Domínguez, I., González-Sánchez, L., López-Nieva, P., Fernández-Navarro, P., Villa-Morales, M., Cobos-Fernández, M.A, Sastre, I., Fraga, M.F., Fernández, A.F., Malumbres, M., Salazar-Roa, M., Graña-Castro, O., Santos, J., Llamas, P., López-Lorenzo, J.L., Fernández-Piqueras, J. (2019) Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma. Oncogene, in press. [PMID:30742097][Full text]

Malumbres, M. (2019) CDK4/6 inhibitors: what is the best cocktail? Clin. Cancer Res25, 6-8. [PMID:30115629][Full text]

Rata, S., Rodriguez, M.F.S.P., Joseph, S., Peter, N., Echegaray-Iturra, F., Yang, F., Madzwamuse, A., Ruppert, J.G., Samejima, K., Platani, M., Álvarez-Fernández, M., Malumbres, M., Earnshaw, W.C., Novak, B. and Hochegger, H. (2018) Two interlinked bistable switches govern mitotic control in mammalian cells. Curr. Biol28, 3824-3832. [PMID:30449668][Full text]

Nguyen, A.L., Drutovic, D., Vázquez, V.N., El Yakoub, W., Gentilello, A.S., Malumbres, M., Solc, P. and Schindler, K. (2018) Genetic interactions between the Aurora kinases reveal new requirements for AURKB and AURKC during oocyte meiosis. Curr. Biol28, 3458-3468.e5. [PMID:30415701][Full text]

Hurtado, B., Trakala, M., Ximénez-Embún, P., El Bakkali, A., Partida, D., Sanz-Castillo, B., Álvarez-Fernández, M., Maroto, M., Sánchez-Martínez, R., Martínez, L., Muñoz, J., García de Frutos, P. & Malumbres, M. (2018) Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets. J. Clin. Invest128, 5351-5367. [PMID:30252678][Full text]

Ovejero, S., Ayala, P., Malumbres, M., Pimentel-Muiños, F.X., Bueno, A. and Sacristán, M.P. (2018) Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1. Sci. Rep8, 11871. [bioRxiv] [PMID:30089874][Full text]

de Cárcer, G.*, Venkateswaran, S.V., Salgueiro, L., El Bakkali, A., Somogyi, K., Rowald, K., Montañes, P., Sanclemente, M., Escobar, B., de Martino, A., McGranahan, N., Malumbres, M.* and Sotillo, R.* (2018). Plk1 overexpression induces chromosomal instability and suppresses tumor development. Nat. Commun. 9, 3012. [*, co-corresponding authors] [BioRxiv] [PMID:30069007][Full text]

Bellutti, F., Tigan, A.S., Nebenfuehr, S., Dolezal, M., Zojer, M., Grausenburger, R., Hartenberger, S., Kollmann, S., Doma, E., Prchal-Murphy, M., Uras, I.Z., Hollein, A., Neuberg, D., Ebert, B.L., Ringler, A., Mueller, A.C., Loizou, J.I., Hinds, P.W., Vogl, C., Heller, G., Kubicek, S., Zuber, J., Malumbres, M., Farlik, M., Villunger, A., Kollmann, K. and Sexl, V. (2018) CDK6 Antoganizes p53-induced responses during tumorigenesis. Cancer Discovery 8, 884-897. [PMID:29899063][Full text]

López-Nieva P., Fernández-Navarro, P., Vaquero-Lorenzo, C., Villa-Morales, M., Graña-Castro, O., Cobos-Fernández, M.Á., López-Lorenzo, J.L., Llamas, P., González-Sanchez, L., Sastre, I., Pollan, M., Malumbres, M., Santos, J. and Fernández-Piqueras, J. (2018) RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas. BMC Cancer 18, 430. [PMID:29661169][Full text]

Mitxelena, J., Apraiz,A., Vallejo-Rodríguez, J., García-Santisteban, I., Fullaondo, A., Alvarez-Fernández, M., Malumbres, M., and Zubiaga, A.M. (2018) An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Nucleic Acids Res46, 4546-4559. [PMID:29590434][Full text]

Álvarez-Fernández, M., Sanz-Flores, M., Sanz-Castillo, B., Salazar-Roa, M., Partida, D., Zapatero-Solana, E., Ali, H.R., Manchado, E., Lowe, S., VanArsdale, T., Shields, D., Caldas, C., Quintela-Fandino, M. and Malumbres, M. (2018) Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer. Cell Death Differ25, 828-840. [PMID:29229993][Full text]

de Cárcer, G., Wachowicz, P., Martínez-Martínez, S., Oller, J., Méndez-Barbero, N., Escobar, B.,  González-Loyola, A., Takaki, T., El Bakkali, A., Cámara, J.A., Jiménez-Borreguero, L.J., Bustelo, X., Cañamero, M., Mulero, F., Sevilla, M.d.l.A., Montero, M.J., Redondo, J.M. and Malumbres, M. (2017) Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. Nat. Med. 23, 964-974. [PMID:28692064][Full text]

Burgess, A., Vuong, J., Rogers, S., Malumbres, M. and O’Donoghue, S.I. (2017) SnapShot: Phosphoregulation of mitosis. Cell 169, 1358-1358e1. [PMID:28622516][Full text]

Ha, K., Ma, C., Lin, H., Tang, L., Lian, Z., Zhao, F., Li, J.-M., Zhen, B., Pei, H., Han, S., Malumbres, M., Jin, J., Chen, H., Zhao, Y., Zhu, Q. and Zhang, P. (2017) The Anaphase Promoting Complex Impacts Repair Choice by Protecting Ubiquitin Signaling at DNA Damage Sites. Nat Commun. 8, 15751. [PMID:28604711][Full text]

Rattani. A., Ballesteros Mejia, R., Roberts, K., Roig, M.B., Godwin, J., Hopkins, M., Eguren, M., Sanchez-Pulido, L., Okaz, E., Ogushi, S., Wolna, M., Metson, J., Pendás, A.M., Malumbres, M., Novák, B., Herbert, M. and Nasmyth, K. (2017) APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity. Curr Biol. 27, 1462-1476. [PMID:28502659][Full text]

Esteban-Martínez, L., Sierra-Filardi, E., McGreal, R.S., Salazar-Roa, M., Mariño, G., Seco, E., Durand, S., Enot, D., Graña, O., Malumbres, M., Cvekl, A., Cuervo, A.M., Kroemer, G. and Boya, P. (2017) Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J. 36, 1688-1706. [PMID:28465321][Full text]

Salazar-Roa, M. and Malumbres, M. (2017) Fueling the cell division cycle. Trends Cell Biol. 27, 69-81. [PMID:27746095][Full text]

Liu, J., Wan, L., Liu, J., Yuan, Z., Zhang, J., Guo, J., Malumbres, M., Liu, J., Zou, W. and Wei, W. (2016) Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discov. 2, 15044. [PMID:27462441][Full text]

Shao, R., Liu, J., Yan, G., Zhang, J., Han, Y., Guo, J., Xu, Z., Yuan, Z., Liu, J., Malumbres, M., Wan, L., Wei, W. and W. Zou. (2016) Cdh1 Regulates Craniofacial Development via APC-dependent Ubiquitination and Activation of Goosecoid. Cell Res. 26, 699-712. [PMID:27126000][Full text]

Blas-Rus, N., Bustos-Morán, E., Pérez de Castro, I., de Cárcer, G., Borroto, A., Camafeita, E., Jorge, I., Vázquez J, Alarcón, B., Malumbres, M., Martín-Cófreces, N.B. and Sánchez-Madrid, F. (2016) Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat. Commun. 7, 11389. [PMID:27091106][Full text]

Hydbring, P., Malumbres, M. and Sicinski, P. (2016) Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nat. Rev. Mol. Cell. Biol. 17, 280-292. [PMID:27033256][Full text]

Malumbres, M. (2016) CDK4/6 inhibitors resTORe therapeutic sensitivity in HER2+ breast cancer. Cancer Cell 29, 243-244. [PMID:26977873][Full text]

Mitxelena, J., Apraiz, A., Vallejo, J., Malumbres, M. and Zubiaga, A. (2016) E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Nucleic Acids Res. 44, 5557-5570. [PMID:26961310][Full text]

Sobecki, M., Mrouj, K., Camasses, A., Parisis, N., Nicolas, E., Llères, D., Gerbe, F., Prieto, S., Krasinska, L., David, A., Eguren, M., Birling, M.-C., Urbach, S., Hem, S., Déjardin, J., Malumbres, M., Jay, P., Dulic, V., Lafontaine, D.L.J., Feil, R.P. and Fisher, D. (2016) The cell proliferation antigen Ki-67 organises heterochromatin. eLife 5, e13722. [PMID:26949251][Full text]

Correia, N.C., Melão, A., Póvoa, V., Sarmento, L., Gómez de Cedrón, M., Malumbres, M., Enguita, F.J. and Barata, J.T. (2106) microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. Oncotarget 7, 8268-8281. [PMID:26882564][Full text]

Quereda, V., Porlan, E., Cañamero, M., Dubus, P. and Malumbres, M. (2016) An essential role for Ink4 and Cip/Kip cell cycle inhibitors in preventing replicative stress. Cell Death Differ. 23, 430-441. [PMID:26292757][Full text]

Búa, S., Sotiropoulou, P., Sgarlata, C., Borlado, L.R., Eguren, M., Domínguez, O., Ortega, S., Malumbres, M., Blanpain, C. and Méndez, J. (2015) Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle. Cell Cycle 14, 3897-3907. [PMID:26697840][Full text]

Malumbres, M. (2015) Keeping order in anaphase. Dev. Cell 35, 403-404. [PMID:26609955][Full text]

Esteban-Martínez, L., Doménech, E., Boya, P. Salazar-Roa, M. and Malumbres, M. (2015) Mitophagy in mitosis: more than a myth. Autophagy 11, 2379-2380. [PMID:26565111][Full text]

Sánchez-Martínez, R., Cruz-Gil, S., Gómez de Cedrón, M., Álvarez-Fernández, M., Vargas, T., Molina, S., García, B., Herranz, J., Moreno-Rubio, J., Reglero, G., Pérez-Moreno, M., Feliú, J., Malumbres, M. and Ramírez de Molina, A. (2015) A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy. Oncotarget 6, 38719-38736. [PMID:26451612][Full text]

Doménech, E., Maestre, C., Esteban-Martínez, L., Partida, D., Pascual, R., Fernández-Miranda, G., Seco, E., Campos-Olivas, R., Pérez, M., Megias, D., Allen, K., López, M., Saha, A.K., Velasco, G., Rial, E., Méndez, R., Boya, P., Salazar-Roa, M. and Malumbres, M. (2015) AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat. Cell Biol. 17, 1304-1316. [PMID:26322680][Full text]

González-Loyola, A., Fernández-Miranda, G., Trakala, M., Partida, D., Samejima, K., Ogawa, H., Cañamero, M., de Martino, A., Martínez-Ramírez, A., de Cárcer, G., Pérez de Castro, I., Earnshaw, W.C. and Malumbres, M. (2015) Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development. Mol. Cell. Biol. 35, 3566-3578. [PMID:26240282][Full text]

Serra, H., Chivite, I., Angulo-Urarte, A., Soler, A., Sutherland, J.D., Arruabarrena-Aristorena, A., Ragab, A., Lim, R., Malumbres, M., Fruttiger, M., Potente, M., Serrano, M., Fabra, A., Viñals, F., Casanovas, O., Pandolfi, P.P., Bigas, A., Carracedo, A., Gerhardt, H. and Graupera, M. (2015) PTEN mediates Notch-dependent stalk cell arrest in angiogenesis. Nat. Commun. 6, 7935. [PMID:26228240][Full text]

Trakala, M., Partida, D., Salazar-Roa, M., Maroto, M., Wachowicz, P. de Cárcer, G. and Malumbres, M. (2015). Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice. Blood 126, 1707-1714. [PMID:26185128][Full text]

Álvarez-Fernández, M. and Malumbres, M. (2015) An atypical oncogene within the atypical E2Fs. J. Natl. Cancer Inst. 107, djv180. [PMID:26089542][Full text]

Huang, J., Ikeuchi, Y., Malumbres, M. and Bonni, A. (2015) A Cdh1-APC/FMRP ubiquitin signaling link drives mGluR-dependent synaptic plasticity in the mammalian brain. Neuron 86, 726-739. [PMID:25913861][Full text]

Penas, C., Govek, E.E., Fang, Y., Ramachandran, V., Daniel, M., Wang, W., Maloof, M.E., Rahaim, R.J., Bibian, M., Kawauchi, D., Finkelstein, D., Han, J.L., Long, J., Li, B., Robbins, D.J., Malumbres, M., Roussel, M.F., Roush, W.R., Hatten, M.E. and Ayad, N.G. (2015) Casein Kinase 1δ is an APC/C-Cdh1 substrate that regulates cerebellar granule cell neurogenesis. Cell Reports 11, 249-260. [PMID:25843713][Full text]

Trakala, M., Rodríguez-Acebes, S., Maroto, M., Symonds, C.E., Santamaría, D., Ortega, S., Barbacid, M., Méndez, J. and Malumbres, M. (2015) Functional reprogramming of polyploidization in megakaryocytes. Dev. Cell 32, 155-167. [PMID:25625205][Full text]

Scheicher, R., Hoelbl-Kovacic, A., Bellutti, F., Tigan, A.S., Prchal-Murphy, M., Heller, G., Schneckenleithner, C., Salazar-Roa, M., Zoechbauer-Mueller, S., Zuber, J., Malumbres, M., Kollmann, K. and Sexl, V. (2015). CDK6 as a key regulator of hematopoietic and leukemic stem cell activation. Blood 125, 90-101. [PMID:25342715][Full text]

Trakala, M. and Malumbres, M. (2014). Cyclin C surprises in tumor suppression. Nat. Cell Biol. 16, 1031-1033. [PMID:25358351][Full text]

Valcárcel, J. and Malumbres, M. (2014). Splicing together sister chromatids. EMBO J. 33, 2601-2603. [PMID:25266476][Full text]

Malumbres, M. and Pérez de Castro, I. (2014). Aurora kinase A inhibitors: promising agents in anti-tumoral therapy. Expert Opin. Ther. Targets 18, 1377-1393. [PMID:25200357][Full text]

Malumbres, M. (2014). Cyclin-dependent kinases. Genome Biol. 15, 122. [PMID:25180339][Full text]

Rodríguez-Díez, E., Quereda, V., Bellutti, F., Prchal-Murphy, M., Partida, D., Eguren, M., Gómez de Cedrón, M., Dubus, P., Cañamero, M., Martínez, L., Sexl, V. and Malumbres, M. (2014) Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis. Blood 124, 2380-2390. [PMID:25157181][Full text]

Piazzolla, D., Palla, A.R., Pantoja, C., Cañamero, M., Pérez de Castro, I., Ortega, S., Gómez-López, G., Dominguez, O., Megías, D., Roncador, G., Luque-Garcia, J.L., Fernandez-Tresguerres, B., Fernandez, A.F., Fraga, M.F., Rodriguez-Justo, M., Manzanares, M., Sánchez-Carbayo, M., García-Pedrero, J.M., Rodrigo, J.P., Malumbres, M. and Serrano, M. (2014) Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat. Commun. 5, 4226. [PMID:24979572][Full text]

Wang, P., Malumbres, M. and Archambault, V. (2014) The Greatwall-PP2A Axis in Cell Cycle Control. Methods Mol. Biol. 1170, 99-111. [PMID:24906311][Full text]

Álvarez-Fernández, M. and Malumbres, M. (2014) Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry. Bioessays 36, 757-765. [PMID:24889070][Full text]

de Cárcer, G. and Malumbres, M. (2014) A centrosomal route for cancer genome instability. Nat. Cell Biol. 16, 504-506. [PMID:24875738][Full text]

Wan, L., Tan, M., Yang, J., Inuzuka, H., Dai, X., Wu, T., Liu, J., Shaik, S., Chen, G., Deng, J., Malumbres, M., Letai, A., Kirschner, M.W., Sun, Y. and Wei, W. (2014) APC-Cdc20 suppresses apoptosis through targeting Bim for ubiquitination and destruction. Dev. Cell 29, 377-391. [PMID:24871945][Full text]

Rattani, A., Vinod, P.K., Godwin, J., Tachibana-Konwalski, K., Wolna, M., Malumbres, M., Novák, B. and Nasmyth, K. (2014). Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible. Curr. Biol. 24, 630-637. [PMID:24583015][Full text]

Eguren, M., Álvarez-Fernández, M., García, F., López-Contreras, A.J., Fujimitsu, K., Yaguchi, H., Luque-García, J.L., Fernández-Capetillo, O., Muñoz, J., Yamano, H. and Malumbres, M. (2014). A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens. Cell Reports 6, 670-683. [PMID:24508461][Full text]

Malumbres, M. (2014) Control of the cell cycle. In: Abeloff’s Clinical Oncology, 5th edition. (Niederhuber, J.E., Armitage, J.O., Doroshow, J.H., Kastan, M.B., and Tepper, J.E., eds.) Elsevier, pp. 52-68. [ISBN: 978-1-4557-2865-7]

Trakala, M. and Malumbres, M. (2014) The functional relevance of polyploidization in the skin. Exp. Dermatol. 23, 92-93. [PMID:24330335][Full text]

Malumbres, M. (2013) Cyclins and Cyclin-dependent kinases. In: Encyclopedia of Systems Biology, (Dubitzky, W., Wolkenhauer, O., Yokota, H. & Cho, K.H., eds.), Springer, Heidelberg. [ISBN 978-1-4419-9864-4]

Malumbres, M. (2013) Mitotic kinases. In: Encyclopedia of Systems Biology (Dubitzky, W., Wolkenhauer, O., Yokota, H. & Cho, K.H., eds), Springer, Heidelberg. [ISBN 978-1-4419-9864-4]

Eguren, M, Porlan, E., Manchado, E., García-Higuera, I., Cañamero, M., Fariñas, I. and Malumbres, M. (2013) The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat. Commun. 4, 2880. [PMID:24301385][Full text]

Pérez de Castro, I., Aguirre-Portolés, C., Fernández-Miranda, G., Cañamero, M., Cowley, D.O., van Dyke, T. and Malumbres, M. (2013) Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res. 73, 6804-6815. [PMID:24242071][Full text]

Tuck, C., Zhang, T., Potapova, T., Malumbres, M. and Novák, B. (2013) Robust mitotic entry is ensured by a latching switch. Biol. Open. 2, 924-931. [PMID:24143279][Full text]

Álvarez-Fernández, M., Sánchez-Martínez, R., Sanz-Castillo, B., Gan, P.P., Sanz-Flores, M., Trakala, M., Ruiz-Torres, M., Lorca, T., Castro., A. and Malumbres, M. (2013) Greatwall is essential to prevent mitotic collapse after nuclear envelop breakdown in mammals. Proc. Natl. Acad. Sci. USA. 110, 17374-17379. [PMID:24101512][Full text]

Frangini, A., Sjöberg, M., Román-Trufero, M., Dharmalingam, G., Haberle, V., Bartke, T., Lenhard, B.,  Malumbres, M., Vidal, M. and Dillon, N. (2013) The Aurora B kinase and the polycomb protein Ring1B combine to regulate active promoters in quiescent lymphocytes. Mol. Cell 51, 647-661. [PMID:24034696][Full text]

Kollmann, K., Heller, G., Schneckenleithner, C., Warsch, W., Scheicher, R., Ott, R.G., Schäfer, M., Fajmann, S., Schlederer, M., Schiefer, A.-I., Reichart, U., Mayerhofer, M., Hoeller, C., Zöchbauer-Müller, S., Kerjaschki, D., Bock, C., Kenner, L., Hoefler, G., Freissmuth, M., Green, A.R., Moriggl, R., Busslinger, M., Malumbres, M. and Sexl, V. (2013) A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell 24, 167-181. [PMID:23948297][Full text]

Kim, J.A., Aberg, C., de Cárcer, G., Malumbres, M., Salvati, A. and Dawson, K.A. (2013) Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest. ACS Nano 7, 7483-7494. [PMID:23941353][Full text]

Doménech, E. and Malumbres, M. (2013) Mitosis-targeting therapies: a troubleshooting guide. Curr. Opin. Pharmacol. 13, 519-528. [PMID:23583638][Full text]

Trakala, M., Fernández-Miranda, G., Pérez de Castro, I., Heeschen, C. and Malumbres, M. (2013) Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1. Cell Cycle 12, 1030-1041. [PMID:23428904][Full text]

González-Gugel, E., Villa-Morales, M., Santos, J., Bueno, M.J., Malumbres, M., Rodríguez-Pinilla, S.M., Piris, M.A. and Fernández-Piqueras, J. (2013) Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development. Carcinogenesis 34, 902-908. [PMID:23288923][Full text]

Michel, C.I. and Malumbres, M. (2013) microRNA-203: tumor suppression and beyond. microRNA 2, 118-126. [PMID:25070781][Full text]

Parrillas, V., Martínez-Muñoz, L., Holgado, B.L., Kumar, A., Cascio, G., Lucas, P., Rodríguez-Frade, J.M., Malumbres, M., Carrera, A.C., van Wely, K.H., Mellado, M. (2013) Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells. Cell. Mol. Life Sci. 70, 545-558. [PMID:23001011][Full text]

Malumbres, M. (2013) miRNAs and cancer: An epigenetics view. Mol. Aspects Med. 34, 863-874. [PMID:22771542][Full text]

Pérez de Castro, I. and Malumbres, M. (2012) Mitotic stress and chromosomal instability in cancer: the case for TPX2. Genes & Cancer 3, 721-730. [PMID:23634259][Full text]

Pick, J.E., Malumbres, M. & Klann, E. (2012) The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice. Learning & Memory 20, 11-20. [PMID:23242419][Full text]

Elorza, A., Soro-Arnáiz, I., Meléndez-Rodríguez, F., Rodríguez-Vaello, V., Marsboom, G., de Cárcer, G., Acosta-Iborra, B., Albacete-Albacete, L., Ordóñez, A., Serrano-Oviedo, L., Giménez-Bachs, J.M., Vara-Vega, A., Salinas, A., Sánchez-Prieto, R., Martín del Río, R., Sánchez-Madrid, F., Malumbres, M., Landázuri, M.O., Aragonés, J. (2012) HIF2a acts as an mTORC1 activator through the amino acid carrier SLC7A5. Mol. Cell 48, 681-691. [PMID:23103253][Full text]

Malumbres, M. (2012) Cell cycle-based therapies move forward. Cancer Cell 22, 419-420. [PMID:23079651][Full text]

de Cárcer, G., Pérez de Castro, I. and Malumbres, M. (2012) Inhibiting cell cycle kinases in cancer therapy. Front. Med. Chem. 6, 154-188. [Full text]

Malumbres, M. (2012) miRNAs versus oncogenes: the power of social networking. Mol. Syst. Biol. 8, 569. [PMID:22333973][Full text]

Aguirre-Portolés, A., Bird, A.W., Hyman, A., Cañamero, M., Pérez de Castro, I. and Malumbres, M. (2012) Tpx2 controls spindle integrity, genome stability and tumor development. Cancer Res. 72, 1518-1528. [PMID:22266221][Full text]

Manchado, E., Guillamot, M. and Malumbres, M. (2012) Killing cells by targeting mitosis. Cell Death Differ. 19, 369-377. [PMID:22223105][Full text]

Guillamot, M., Manchado, E., Chiesa, M., Gómez-López, G., Pisano, D.G., Sacristán, M. and Malumbres, M. (2011) Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. Sci. Reports 1, 189. [PMID:22355704][Full text]

Wan, L., Zou, W., Gao, D., Inuzuka, Fukushima, H., Berg, A.H., Drapp, R., Shaik, S., Hu, D., Lester, C., Eguren, M., Malumbres, M., Glimcher, L.H. and Wei, W. (2011) Cdh1 Regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol. Cell 44, 721-733. [PMID:22152476][Full text]

Santamaría, D. and Malumbres, M. (2011) Tumor suppression by Spinophilin. Cell Cycle 10, 2831-2832. [PMID:21869595][Full text]

Malumbres, M. (2011) Physiological relevance of cell cycle kinases. Physiol. Rev. 91, 973-1007. [PMID:21742793][Full text]

Malumbres, M. (2011) Oncogene-induced mitotic stress: p53 and pRb get Mad too. Cancer Cell 19, 691-692. [PMID:21665141][Full text]

de Cárcer, G., Manning, G. and Malumbres, M. (2011) From Plk1 to Plk5: functional evolution of Polo-like kinases. Cell Cycle 10, 2255-2262. [PMID:21654194][Full text]

Fernández-Miranda, G., Trakala, M., Martín, J., Escobar, B., González, A., Ghyselinck, N.B., Ortega, S., Cañamero, M., Pérez de Castro, I. and Malumbres, M. (2011) Genetic disruption of Aurora B uncovers an essential role for Aurora C during early mammalian development. Development 138, 2661-2672. [PMID:21613325][Full text]

Chiesa, M.,* Guillamot, M.,* Bueno, M.J. and Malumbres, M. (2011) The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway. Cell Cycle 10, 1607-1617. [PMID:21502810][Full text]

Bueno, M.J., Gómez de Cedrón, M., Gómez-López, G., Pérez de Castro, I., di Lisio, L., Montes, S., Martínez, N., Guerrero, M., Sánchez, R., Santos, J., Pisano, D.G., Piris, M.A., Fernández-Piqueras, J. and Malumbres, M. (2011) Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway. Blood 117, 6255-6266. [PMID:21478429][Full text]

Eguren, M., Manchado, E. and Malumbres, M. (2011) Non-mitotic functions of the Anaphase-Promoting Complex. Semin. Cell Dev. Biol. 22, 572-578. [PMID:21439391][Full text]

Manchado, E. and Malumbres, M. (2011) Targeting aneuploidy for cancer therapy. Cell 144, 465-466. [PMID:21335229][Full text]

Bueno, M.J. and Malumbres, M. (2011) microRNAs and the cell cycle. Biochim. Biophys. Acta 1812, 592-601. [PMID:21315819][Full text]

Kollmann, K., Heller, G., Ott, R.G., Scheicher, R., Zebedin-Brandl, E., Schneckenleithner, C., Simma, O., Warsch, W., Eckelhart, E., Hoelbl, A., Bilban, M., Zöchbauer-Müller, S., Malumbres, M. and Sexl, V. (2011) C-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5’ region of Cdk6. Blood 117, 4065-4075. [PMID:21300982][Full text]

de Cárcer, G., Escobar, B., Higuero, A., García, L., Ansón, A., Pérez, G., Mollejo, M., Manning, G., Melendez, B., Abad-Rodriguez, J. and Malumbres, M. (2011) Plk5, a Polo-box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol. Cell. Biol. 31, 1225-1239. [PMID:21245385][Full text]

Song, M.S., Carracedo, A., Salmena, L., Song, S.J., Egia, A., Malumbres, M. and Pandolfi, P.P. (2011) Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144, 187-199. [PMID:21241890][Full text]

Pérez de Castro, I., Aguirre-Portolés, C., Martin, B., Fernández-Miranda, G., Klotzbucher, A., Kubbutat, M.H.G., Megías, D., Arlot-Bonnemains, Y. and Malumbres, M. (2011) A SUMOylation Motif in Aurora-A: Implications in Spindle Dynamics and Oncogenesis. Front. Oncol. 1, 50. [PMID:22649767][Full text]

Muñoz, I.G., Yébenes, H., Zhou, M., Mesa, P., Serna, M., Park, A.Y., Bragado-Nilsson, E., Beloso, A., de Cárcer, G., Malumbres, M., Robinson, C.V., Valpuesta, J.M. and Montoya, G. (2011) Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin. Nat. Struct. Mol. Biol. 18, 14-19. [PMID:21151115][Full text]

Manchado, E., Guillamot, M., de Cárcer, G., Eguren, M., Trickey, M., García-Higuera, I., Moreno, S., Yamano, H., Cañamero, M. and Malumbres, M. (2010) Targeting mitotic exit leads to tumor regression in vivo: modulation by Cdk1, Mastl, and the PP2A/B55a,d phosphatase. Cancer Cell 18, 641-654. [PMID:21156286][Full text]

Santibanez, J.F., Pérez-Gómez, E., Fernandez-L, A., Garrido-Martín, E., Carnero, A., Malumbres, M., Vary, C.P.H., Quintanilla, M. and Bernabéu, C. (2010) The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras. Carcinogenesis 31, 2145-2154. [PMID:20884686][Full text]

Escobar, B., de Cárcer, G., Fernández-Miranda, G., Cascón, A., Bravo-Cordero, J.J., Montoya, M.C., Robledo, M., Cañamero, M. and Malumbres, M. (2010) Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation. Cancer Res. 70, 9349-9359. [PMID:20861187][Full text]

Fernández-Miranda, G., Pérez de Castro, I., Carmena, M., Aguirre-Portolés, C., Ruchaud, S., Fant, X., Montoya, G., Earnshaw, W.C. and Malumbres, M. (2010) Modulation of Aurora B function by SUMOylation. J. Cell Sci. 123, 2823-2833. [PMID:20663916][Full text]

Mourón, S., de Cárcer, G., Seco, E., Fernández-Miranda, G., Malumbres, M. and Nebreda, A.R.  (2010) RINGO/Speedy C is required to sustain the spindle assembly checkpoint. J. Cell Sci. 123, 2586-2595. [PMID:20605920][Full text]

Bueno, M.J., Gómez de Cedrón, M., Laresgoiti, U., Fernández-Piqueras, J., Zubiaga, A. and Malumbres, M. (2010) Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signalling. Mol. Cell. Biol. 30, 2983-2995. [PMID:20404092][Full text]

Manchado, E., Eguren, M. and Malumbres, M. (2010) The anaphase promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions. Biochem. Soc. Trans. 38, 65-71. [PMID:20074037][Full text]

Gurden, M.D.J., Holland, A.J., van Zon, W., Tighe, A., Vergnolle, M.A., Andres, D.A., Spielmann, H.P., Malumbres, M., Wolthuis, R.M.F., Cleveland, D.W. and Taylor, S.S. (2010) Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J. Cell. Sci. 123, 321-330. [PMID:20053638][Full text]

Malumbres, M.,* Edward Harlow, Tim Hunt, Tony Hunter, Jill M. Lahti, Gerard Manning, David O. Morgan, Li-Huei Tsai, and Debra J. Wolgemuth (2009) Cyclin-dependent kinases: a family portrait. Nat. Cell Biol. 11, 1275-1276. [*Corresponding author] [PMID:19884882][Full text]

Garcia-Lavandeira, M.,  Quereda, V., Flores, I., Saez, C., Diaz-Rodriguez, E., Japon, M.A., Ryan, A.K., Blasco, M.A., Dieguez, C., Malumbres, M.* and Alvarez, C.V.* (2009) A GRFa2/Prop1/Stem (GPS) Cell Niche in the Pituitary. PLoS One 4, e4815. [* Co-corresponding authors] [PMID:19283075][Full text]

Malumbres, M. and Barbacid, M. (2009) Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev Cancer 9, 153-166. [PMID:19238148][Full text]

Muñoz, P., Blanco, R., de Carcer, R., Schoeftner, S., Benetti, R., Flores, J.M., Malumbres, M. and Blasco, M.A. (2009) TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol. Cell. Biol. 29, 1608-1625. [PMID:19124610][Full text]

Quereda, V., and Malumbres, M. (2009) Cell Cycle Control of Pituitary Development and Disease. J. Mol. Endocrinol. 42, 75-86. [PMID:18987159][Full text]

Infante, A., Laresgoiti, U., Fernández-Rueda, J., Fullaondo, A., Galán, J., Díaz-Uriarte, R., Malumbres, M., Field, S.J. and Zubiaga, A.M. (2008) E2F2 Represses Cell Cycle Regulators to Maintain Quiescence. Cell Cycle 7, 3915-3927. [PMID:19066456][Full text]

Bueno, M.J., Pérez de Castro, I. and Malumbres, M. (2008). Control of cell proliferation pathways by microRNAs. Cell Cycle 7, 3143-3148. [PMID:18843198][Full text]

Pérez de Castro, I., de Cárcer, G., Montoya, G. and Malumbres, M. (2008) Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Curr. Opin. Pharmacol. 8, 375-383. [PMID:18644252][Full text]

García-Higuera, I., Manchado, E., Dubus, P., Cañamero, M., Mendez, J., Moreno, S. and Malumbres, M. (2008) Genomic Stability and Tumor Suppression by the APC/C Cofactor Cdh1. Nat. Cell Biol. 10, 802-811. [PMID:18552834][Full text]

Bueno, M.J., Pérez de Castro, I., Gómez de Cedrón, M., Santos, J., Calin, G.A., Cigudosa, J.C., Croce, C.M., Fernández-Piqueras, J. and Malumbres, M. (2008) Genetic and Epigenetic Silencing of microRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression. Cancer Cell 13, 496-506. [PMID:18538733][Full text]

Malumbres, M., Pevarello, P., Barbacid, M. and Bischoff, J.R. (2008) CDK inhibitors in cancer therapy: What is next? Trends Pharmacol Sci. 29, 16-21. [PMID:18054800][Full text]

Malumbres, M. (2007) Cyclins and related kinases in cancer cells. J. BUON 12, S45-S52. [PMID:17935277]

Santamaría, D., Barrière, C., Cerqueira, A., Hunt, S.L., Tardy, C., Newton, K., Cáceres, J.F., Dubus, P., Malumbres, M. and Barbacid, M. (2007) Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448, 811-815. [PMID:17700700][Full text]

Malumbres, M. (2007) Cyclin-dependent kinases and their regulators as potential targets for anticancer therapeutics. In: Principles of Molecular Oncology, Bronchud, ed. Humana Press, pp. 204-235.[Full text]

Quereda, V., Martinalbo, J., Dubus, P., Carnero, A. and Malumbres, M. (2007) Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene 26, 7665-7674. [PMID:17599058][Full text]

Barrière, C., Santamaría, D., Cerqueira, A., Galán, J., Martín, A., Ortega, S., Malumbres, M., Dubus, P. and Barbacid, M. (2007) Mice thrive without Cdk4 and Cdk2. Mol. Oncol. 1, 72-83. [PMID:19383288][Full text]

de Cárcer, G.; Pérez de Castro, I. and Malumbres, M. (2007) Targeting cell cycle kinases for cancer therapy. Curr. Med. Chem. 14, 969-985. [PMID:17439397][Full text]

Cascón, A.,* Escobar, B.,* Montero-Conde, C., Rodríguez-Antona, C., Ruiz-Llorente, S., Osorio, A., Mercadillo, F., Letón, R., de Campos, J.M., García-Sagredo, J.M., Benítez, J., Malumbres, M. and Robledo, M. (2007) Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients. Hum. Mutat. 28, 613-621. [* Co-corresponding authors]. [PMID:17311301][Full text]

Pérez de Castro, I., de Cárcer, G. and Malumbres, M. (2007) A census of mitotic cancer genes. New insights into tumor cell biology and cancer therapy. Carcinogenesis 28, 899-912. [PMID:17259655][Full text]

Malumbres, M. and Barbacid, M. (2007) Cell cycle kinases in cancer. Curr. Opin. Genet. Dev. 17, 60-65. [PMID:17208431][Full text]

Malumbres, M. (2006) Preclinical models for cell cycle-targeted therapies. Adv. Exp. Med. Biol. 587, 139-147. [PMID:17163163][Full text]

Blazquez, C., Carracedo, A., Barrado, L., Real, P.J., Fernández-Luna, J.L., Velasco, G., Malumbres, M. and Guzman, M. (2006) Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J. 20, 2633-2635. [PMID:17065222][Full text]

Tormo, D., Ferrer, A., Gaffal, E., Wenzel, J., Basner-Tschakarjan, E., Steitz, J., Heukamp, L.C., Gutgemann, I., Buettner, R., Malumbres, M., Barbacid, M., Merlino, G., Tuting, T. (2006). Rapid Growth of Invasive Metastatic Melanoma in Carcinogen-Treated Hepatocyte Growth Factor/Scatter Factor-Transgenic Mice Carrying an Oncogenic CDK4 Mutation. Am. J. Pathol. 169, 665-672. [PMID:16877364][Full text]

Malumbres, M. (2006) Therapeutic opportunities to control tumor cell cycles. Clin. Transl. Oncol. 8, 399-408. [PMID:16790392][Full text]

Hacker, E., Muller, H.K., Irwin, N., Gabrielli, B., Lincoln, D., Pavey, S., Powell, M.B., Malumbres, M., Barbacid, M., Hayward, N. and Walker, G. (2006) Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Res. 66, 2946-2952. [PMID:16540642][Full text]

Malumbres, M. and Barbacid, M. (2006) Is Cyclin D1/Cdk4 kinase a bona-fide cancer target? Cancer Cell 9, 2-4. [PMID:16413464][Full text]

Malumbres, M., Dubus, P. and Ortega, S. (2006) Mouse models to study the in vivo function of Cyclin-dependent kinases in normal homeostasis and tumor development. In: Inhibitors of cyclin-dependent kinases as anti-tumor agents (Smith, P.J. and Yue, E.W., eds.) CRC Press, Boca Raton. pp. 55-83.[Full text]

Duensing, A., Liu, Y., Tseng, M., Malumbres, M., Barbacid, M. and Duesing, S. (2006) Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene 25, 2943-2949. [PMID:16331279][Full text]

Steitz, J., Büchs, S., Tormo, D., Ferrer, A., Wenzel, J., Huber, C., Wölfel, T., Barbacid, M., Malumbres, M. and Tüting, T. (2006) Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin. Int. J. Cancer 118, 373-380. [PMID:16049960][Full text]

Malumbres, M. and Barbacid, M. (2005) Mammalian cyclin-dependent kinases. Trends Biochem. Sci., 30, 630-641. [PMID:16236519][Full text]

Barbacid, M., Ortega, S., Sotillo, R., Odajima, J., Martín, A., Santamaría, D., Dubus, P. and Malumbres, M. (2005) Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases. Cold Spring Harb. Symp. Quant. Biol. 70, 233-240. [Full text]

Abella, A., Dubus, P., Malumbres, M., Rane, S.G., Kiyokawa, H., Sicard, A., Vignon, F., Langin, D., Barbacid, M. and Fajas, L. (2005) Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metabolism 2, 239-249. [PMID:16213226][Full text]

Martín, A., Odajima, J., Hunt, S.L., Dubus, P., Ortega, S., Malumbres, M.* and Barbacid, M.* (2005) Cell Cycle Inhibition and Tumor Suppression by p21Cip1 and p27Kip1 are Independent of Cdk2. Cancer Cell 7, 591-598. [*Co-corresponding authors] [PMID:15950907][Full text]

Sotillo, R., Renner, O., Dubus, P., Ruiz-Cabello, J., Martín-Caballero, J., Barbacid, M., Carnero, A. and Malumbres, M. (2005) Cooperation Between Cdk4 and p27Kip1 in Tumor Development: a Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity. Cancer Res. 65, 3846-3852. [PMID:15867383][Full text]

Pérez de Castro, I., Benet, M., Jiménez, M., Alzabin, S., Malumbres, M. and Pellicer, A. (2005) Mouse p10, an alternative spliced form of p15INK4b, inhibits cell cycle progression and malignant transformation. Cancer Res. 65, 3249-3256. [PMID:15833857][Full text]

Malumbres, M. (2005) Revisiting the “Cdk-centric” view of the mammalian cell cycle. Cell Cycle 4, 206-210. [PMID:15655365][Full text]

2019

Bustos-Morán, E., Blas-Rus, N., Alcaraz-Serna, A., Iborra, S., González-Martínez, J., Malumbres, M., Sánchez-Madrid, F. (2019) Aurora A controls CD8+ T cell cytotoxic activity and antiviral response. Sci Rep. 9, 2211. [PMID:30778113][Full text]

Vázquez-Domínguez, I., González-Sánchez, L., López-Nieva, P., Fernández-Navarro, P., Villa-Morales, M., Cobos-Fernández, M.A, Sastre, I., Fraga, M.F., Fernández, A.F., Malumbres, M., Salazar-Roa, M., Graña-Castro, O., Santos, J., Llamas, P., López-Lorenzo, J.L., Fernández-Piqueras, J. (2019) Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma. Oncogene, in press. [PMID:30742097][Full text]

Malumbres, M. (2019) CDK4/6 inhibitors: what is the best cocktail? Clin. Cancer Res25, 6-8. [PMID:30115629][Full text]

2018

Rata, S., Rodriguez, M.F.S.P., Joseph, S., Peter, N., Echegaray-Iturra, F., Yang, F., Madzwamuse, A., Ruppert, J.G., Samejima, K., Platani, M., Álvarez-Fernández, M., Malumbres, M., Earnshaw, W.C., Novak, B. and Hochegger, H. (2018) Two interlinked bistable switches govern mitotic control in mammalian cells. Curr. Biol28, 3824-3832. [PMID:30449668][Full text]

Nguyen, A.L., Drutovic, D., Vázquez, V.N., El Yakoub, W., Gentilello, A.S., Malumbres, M., Solc, P. and Schindler, K. (2018) Genetic interactions between the Aurora kinases reveal new requirements for AURKB and AURKC during oocyte meiosis. Curr. Biol28, 3458-3468.e5. [PMID:30415701][Full text]

Hurtado, B., Trakala, M., Ximénez-Embún, P., El Bakkali, A., Partida, D., Sanz-Castillo, B., Álvarez-Fernández, M., Maroto, M., Sánchez-Martínez, R., Martínez, L., Muñoz, J., García de Frutos, P. & Malumbres, M. (2018) Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets. J. Clin. Invest128, 5351-5367. [PMID:30252678][Full text]

Ovejero, S., Ayala, P., Malumbres, M., Pimentel-Muiños, F.X., Bueno, A. and Sacristán, M.P. (2018) Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1. Sci. Rep8, 11871. [bioRxiv] [PMID:30089874][Full text]

de Cárcer, G.*, Venkateswaran, S.V., Salgueiro, L., El Bakkali, A., Somogyi, K., Rowald, K., Montañes, P., Sanclemente, M., Escobar, B., de Martino, A., McGranahan, N., Malumbres, M.* and Sotillo, R.* (2018). Plk1 overexpression induces chromosomal instability and suppresses tumor development. Nat. Commun. 9, 3012. [*, co-corresponding authors] [BioRxiv] [PMID:30069007][Full text]

Bellutti, F., Tigan, A.S., Nebenfuehr, S., Dolezal, M., Zojer, M., Grausenburger, R., Hartenberger, S., Kollmann, S., Doma, E., Prchal-Murphy, M., Uras, I.Z., Hollein, A., Neuberg, D., Ebert, B.L., Ringler, A., Mueller, A.C., Loizou, J.I., Hinds, P.W., Vogl, C., Heller, G., Kubicek, S., Zuber, J., Malumbres, M., Farlik, M., Villunger, A., Kollmann, K. and Sexl, V. (2018) CDK6 Antoganizes p53-induced responses during tumorigenesis. Cancer Discovery 8, 884-897. [PMID:29899063][Full text]

López-Nieva P., Fernández-Navarro, P., Vaquero-Lorenzo, C., Villa-Morales, M., Graña-Castro, O., Cobos-Fernández, M.Á., López-Lorenzo, J.L., Llamas, P., González-Sanchez, L., Sastre, I., Pollan, M., Malumbres, M., Santos, J. and Fernández-Piqueras, J. (2018) RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas. BMC Cancer 18, 430. [PMID:29661169][Full text]

Mitxelena, J., Apraiz,A., Vallejo-Rodríguez, J., García-Santisteban, I., Fullaondo, A., Alvarez-Fernández, M., Malumbres, M., and Zubiaga, A.M. (2018) An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Nucleic Acids Res46, 4546-4559. [PMID:29590434][Full text]

Álvarez-Fernández, M., Sanz-Flores, M., Sanz-Castillo, B., Salazar-Roa, M., Partida, D., Zapatero-Solana, E., Ali, H.R., Manchado, E., Lowe, S., VanArsdale, T., Shields, D., Caldas, C., Quintela-Fandino, M. and Malumbres, M. (2018) Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer. Cell Death Differ25, 828-840. [PMID:29229993][Full text]

2017

de Cárcer, G., Wachowicz, P., Martínez-Martínez, S., Oller, J., Méndez-Barbero, N., Escobar, B.,  González-Loyola, A., Takaki, T., El Bakkali, A., Cámara, J.A., Jiménez-Borreguero, L.J., Bustelo, X., Cañamero, M., Mulero, F., Sevilla, M.d.l.A., Montero, M.J., Redondo, J.M. and Malumbres, M. (2017) Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. Nat. Med. 23, 964-974. [PMID:28692064][Full text]

Burgess, A., Vuong, J., Rogers, S., Malumbres, M. and O’Donoghue, S.I. (2017) SnapShot: Phosphoregulation of mitosis. Cell 169, 1358-1358e1. [PMID:28622516][Full text]

Ha, K., Ma, C., Lin, H., Tang, L., Lian, Z., Zhao, F., Li, J.-M., Zhen, B., Pei, H., Han, S., Malumbres, M., Jin, J., Chen, H., Zhao, Y., Zhu, Q. and Zhang, P. (2017) The Anaphase Promoting Complex Impacts Repair Choice by Protecting Ubiquitin Signaling at DNA Damage Sites. Nat Commun. 8, 15751. [PMID:28604711][Full text]

Rattani. A., Ballesteros Mejia, R., Roberts, K., Roig, M.B., Godwin, J., Hopkins, M., Eguren, M., Sanchez-Pulido, L., Okaz, E., Ogushi, S., Wolna, M., Metson, J., Pendás, A.M., Malumbres, M., Novák, B., Herbert, M. and Nasmyth, K. (2017) APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity. Curr Biol. 27, 1462-1476. [PMID:28502659][Full text]

Esteban-Martínez, L., Sierra-Filardi, E., McGreal, R.S., Salazar-Roa, M., Mariño, G., Seco, E., Durand, S., Enot, D., Graña, O., Malumbres, M., Cvekl, A., Cuervo, A.M., Kroemer, G. and Boya, P. (2017) Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J. 36, 1688-1706. [PMID:28465321][Full text]

Salazar-Roa, M. and Malumbres, M. (2017) Fueling the cell division cycle. Trends Cell Biol. 27, 69-81. [PMID:27746095][Full text]

2016

Liu, J., Wan, L., Liu, J., Yuan, Z., Zhang, J., Guo, J., Malumbres, M., Liu, J., Zou, W. and Wei, W. (2016) Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discov. 2, 15044. [PMID:27462441][Full text]

Shao, R., Liu, J., Yan, G., Zhang, J., Han, Y., Guo, J., Xu, Z., Yuan, Z., Liu, J., Malumbres, M., Wan, L., Wei, W. and W. Zou. (2016) Cdh1 Regulates Craniofacial Development via APC-dependent Ubiquitination and Activation of Goosecoid. Cell Res. 26, 699-712. [PMID:27126000][Full text]

Blas-Rus, N., Bustos-Morán, E., Pérez de Castro, I., de Cárcer, G., Borroto, A., Camafeita, E., Jorge, I., Vázquez J, Alarcón, B., Malumbres, M., Martín-Cófreces, N.B. and Sánchez-Madrid, F. (2016) Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat. Commun. 7, 11389. [PMID:27091106][Full text]

Hydbring, P., Malumbres, M. and Sicinski, P. (2016) Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nat. Rev. Mol. Cell. Biol. 17, 280-292. [PMID:27033256][Full text]

Malumbres, M. (2016) CDK4/6 inhibitors resTORe therapeutic sensitivity in HER2+ breast cancer. Cancer Cell 29, 243-244. [PMID:26977873][Full text]

Mitxelena, J., Apraiz, A., Vallejo, J., Malumbres, M. and Zubiaga, A. (2016) E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Nucleic Acids Res. 44, 5557-5570. [PMID:26961310][Full text]

Sobecki, M., Mrouj, K., Camasses, A., Parisis, N., Nicolas, E., Llères, D., Gerbe, F., Prieto, S., Krasinska, L., David, A., Eguren, M., Birling, M.-C., Urbach, S., Hem, S., Déjardin, J., Malumbres, M., Jay, P., Dulic, V., Lafontaine, D.L.J., Feil, R.P. and Fisher, D. (2016) The cell proliferation antigen Ki-67 organises heterochromatin. eLife 5, e13722. [PMID:26949251][Full text]

Correia, N.C., Melão, A., Póvoa, V., Sarmento, L., Gómez de Cedrón, M., Malumbres, M., Enguita, F.J. and Barata, J.T. (2106) microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. Oncotarget 7, 8268-8281. [PMID:26882564][Full text]

Quereda, V., Porlan, E., Cañamero, M., Dubus, P. and Malumbres, M. (2016) An essential role for Ink4 and Cip/Kip cell cycle inhibitors in preventing replicative stress. Cell Death Differ. 23, 430-441. [PMID:26292757][Full text]

2015

Búa, S., Sotiropoulou, P., Sgarlata, C., Borlado, L.R., Eguren, M., Domínguez, O., Ortega, S., Malumbres, M., Blanpain, C. and Méndez, J. (2015) Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle. Cell Cycle 14, 3897-3907. [PMID:26697840][Full text]

Malumbres, M. (2015) Keeping order in anaphase. Dev. Cell 35, 403-404. [PMID:26609955][Full text]

Esteban-Martínez, L., Doménech, E., Boya, P. Salazar-Roa, M. and Malumbres, M. (2015) Mitophagy in mitosis: more than a myth. Autophagy 11, 2379-2380. [PMID:26565111][Full text]

Sánchez-Martínez, R., Cruz-Gil, S., Gómez de Cedrón, M., Álvarez-Fernández, M., Vargas, T., Molina, S., García, B., Herranz, J., Moreno-Rubio, J., Reglero, G., Pérez-Moreno, M., Feliú, J., Malumbres, M. and Ramírez de Molina, A. (2015) A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy. Oncotarget 6, 38719-38736. [PMID:26451612][Full text]

Doménech, E., Maestre, C., Esteban-Martínez, L., Partida, D., Pascual, R., Fernández-Miranda, G., Seco, E., Campos-Olivas, R., Pérez, M., Megias, D., Allen, K., López, M., Saha, A.K., Velasco, G., Rial, E., Méndez, R., Boya, P., Salazar-Roa, M. and Malumbres, M. (2015) AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat. Cell Biol. 17, 1304-1316. [PMID:26322680][Full text]

González-Loyola, A., Fernández-Miranda, G., Trakala, M., Partida, D., Samejima, K., Ogawa, H., Cañamero, M., de Martino, A., Martínez-Ramírez, A., de Cárcer, G., Pérez de Castro, I., Earnshaw, W.C. and Malumbres, M. (2015) Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development. Mol. Cell. Biol. 35, 3566-3578. [PMID:26240282][Full text]

Serra, H., Chivite, I., Angulo-Urarte, A., Soler, A., Sutherland, J.D., Arruabarrena-Aristorena, A., Ragab, A., Lim, R., Malumbres, M., Fruttiger, M., Potente, M., Serrano, M., Fabra, A., Viñals, F., Casanovas, O., Pandolfi, P.P., Bigas, A., Carracedo, A., Gerhardt, H. and Graupera, M. (2015) PTEN mediates Notch-dependent stalk cell arrest in angiogenesis. Nat. Commun. 6, 7935. [PMID:26228240][Full text]

Trakala, M., Partida, D., Salazar-Roa, M., Maroto, M., Wachowicz, P. de Cárcer, G. and Malumbres, M. (2015). Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice. Blood 126, 1707-1714. [PMID:26185128][Full text]

Álvarez-Fernández, M. and Malumbres, M. (2015) An atypical oncogene within the atypical E2Fs. J. Natl. Cancer Inst. 107, djv180. [PMID:26089542][Full text]

Huang, J., Ikeuchi, Y., Malumbres, M. and Bonni, A. (2015) A Cdh1-APC/FMRP ubiquitin signaling link drives mGluR-dependent synaptic plasticity in the mammalian brain. Neuron 86, 726-739. [PMID:25913861][Full text]

Penas, C., Govek, E.E., Fang, Y., Ramachandran, V., Daniel, M., Wang, W., Maloof, M.E., Rahaim, R.J., Bibian, M., Kawauchi, D., Finkelstein, D., Han, J.L., Long, J., Li, B., Robbins, D.J., Malumbres, M., Roussel, M.F., Roush, W.R., Hatten, M.E. and Ayad, N.G. (2015) Casein Kinase 1δ is an APC/C-Cdh1 substrate that regulates cerebellar granule cell neurogenesis. Cell Reports 11, 249-260. [PMID:25843713][Full text]

Trakala, M., Rodríguez-Acebes, S., Maroto, M., Symonds, C.E., Santamaría, D., Ortega, S., Barbacid, M., Méndez, J. and Malumbres, M. (2015) Functional reprogramming of polyploidization in megakaryocytes. Dev. Cell 32, 155-167. [PMID:25625205][Full text]

Scheicher, R., Hoelbl-Kovacic, A., Bellutti, F., Tigan, A.S., Prchal-Murphy, M., Heller, G., Schneckenleithner, C., Salazar-Roa, M., Zoechbauer-Mueller, S., Zuber, J., Malumbres, M., Kollmann, K. and Sexl, V. (2015). CDK6 as a key regulator of hematopoietic and leukemic stem cell activation. Blood 125, 90-101. [PMID:25342715][Full text]

2014

Trakala, M. and Malumbres, M. (2014). Cyclin C surprises in tumor suppression. Nat. Cell Biol. 16, 1031-1033. [PMID:25358351][Full text]

Valcárcel, J. and Malumbres, M. (2014). Splicing together sister chromatids. EMBO J. 33, 2601-2603. [PMID:25266476][Full text]

Malumbres, M. and Pérez de Castro, I. (2014). Aurora kinase A inhibitors: promising agents in anti-tumoral therapy. Expert Opin. Ther. Targets 18, 1377-1393. [PMID:25200357][Full text]

Malumbres, M. (2014). Cyclin-dependent kinases. Genome Biol. 15, 122. [PMID:25180339][Full text]

Rodríguez-Díez, E., Quereda, V., Bellutti, F., Prchal-Murphy, M., Partida, D., Eguren, M., Gómez de Cedrón, M., Dubus, P., Cañamero, M., Martínez, L., Sexl, V. and Malumbres, M. (2014) Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis. Blood 124, 2380-2390. [PMID:25157181][Full text]

Piazzolla, D., Palla, A.R., Pantoja, C., Cañamero, M., Pérez de Castro, I., Ortega, S., Gómez-López, G., Dominguez, O., Megías, D., Roncador, G., Luque-Garcia, J.L., Fernandez-Tresguerres, B., Fernandez, A.F., Fraga, M.F., Rodriguez-Justo, M., Manzanares, M., Sánchez-Carbayo, M., García-Pedrero, J.M., Rodrigo, J.P., Malumbres, M. and Serrano, M. (2014) Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat. Commun. 5, 4226. [PMID:24979572][Full text]

Wang, P., Malumbres, M. and Archambault, V. (2014) The Greatwall-PP2A Axis in Cell Cycle Control. Methods Mol. Biol. 1170, 99-111. [PMID:24906311][Full text]

Álvarez-Fernández, M. and Malumbres, M. (2014) Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry. Bioessays 36, 757-765. [PMID:24889070][Full text]

de Cárcer, G. and Malumbres, M. (2014) A centrosomal route for cancer genome instability. Nat. Cell Biol. 16, 504-506. [PMID:24875738][Full text]

Wan, L., Tan, M., Yang, J., Inuzuka, H., Dai, X., Wu, T., Liu, J., Shaik, S., Chen, G., Deng, J., Malumbres, M., Letai, A., Kirschner, M.W., Sun, Y. and Wei, W. (2014) APC-Cdc20 suppresses apoptosis through targeting Bim for ubiquitination and destruction. Dev. Cell 29, 377-391. [PMID:24871945][Full text]

Rattani, A., Vinod, P.K., Godwin, J., Tachibana-Konwalski, K., Wolna, M., Malumbres, M., Novák, B. and Nasmyth, K. (2014). Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible. Curr. Biol. 24, 630-637. [PMID:24583015][Full text]

Eguren, M., Álvarez-Fernández, M., García, F., López-Contreras, A.J., Fujimitsu, K., Yaguchi, H., Luque-García, J.L., Fernández-Capetillo, O., Muñoz, J., Yamano, H. and Malumbres, M. (2014). A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens. Cell Reports 6, 670-683. [PMID:24508461][Full text]

Malumbres, M. (2014) Control of the cell cycle. In: Abeloff’s Clinical Oncology, 5th edition. (Niederhuber, J.E., Armitage, J.O., Doroshow, J.H., Kastan, M.B., and Tepper, J.E., eds.) Elsevier, pp. 52-68. [ISBN: 978-1-4557-2865-7]

Trakala, M. and Malumbres, M. (2014) The functional relevance of polyploidization in the skin. Exp. Dermatol. 23, 92-93. [PMID:24330335][Full text]

2013

Malumbres, M. (2013) Cyclins and Cyclin-dependent kinases. In: Encyclopedia of Systems Biology, (Dubitzky, W., Wolkenhauer, O., Yokota, H. & Cho, K.H., eds.), Springer, Heidelberg. [ISBN 978-1-4419-9864-4]

Malumbres, M. (2013) Mitotic kinases. In: Encyclopedia of Systems Biology (Dubitzky, W., Wolkenhauer, O., Yokota, H. & Cho, K.H., eds), Springer, Heidelberg. [ISBN 978-1-4419-9864-4]

Eguren, M, Porlan, E., Manchado, E., García-Higuera, I., Cañamero, M., Fariñas, I. and Malumbres, M. (2013) The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat. Commun. 4, 2880. [PMID:24301385][Full text]

Pérez de Castro, I., Aguirre-Portolés, C., Fernández-Miranda, G., Cañamero, M., Cowley, D.O., van Dyke, T. and Malumbres, M. (2013) Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res. 73, 6804-6815. [PMID:24242071][Full text]

Tuck, C., Zhang, T., Potapova, T., Malumbres, M. and Novák, B. (2013) Robust mitotic entry is ensured by a latching switch. Biol. Open. 2, 924-931. [PMID:24143279][Full text]

Álvarez-Fernández, M., Sánchez-Martínez, R., Sanz-Castillo, B., Gan, P.P., Sanz-Flores, M., Trakala, M., Ruiz-Torres, M., Lorca, T., Castro., A. and Malumbres, M. (2013) Greatwall is essential to prevent mitotic collapse after nuclear envelop breakdown in mammals. Proc. Natl. Acad. Sci. USA. 110, 17374-17379. [PMID:24101512][Full text]

Frangini, A., Sjöberg, M., Román-Trufero, M., Dharmalingam, G., Haberle, V., Bartke, T., Lenhard, B.,  Malumbres, M., Vidal, M. and Dillon, N. (2013) The Aurora B kinase and the polycomb protein Ring1B combine to regulate active promoters in quiescent lymphocytes. Mol. Cell 51, 647-661. [PMID:24034696][Full text]

Kollmann, K., Heller, G., Schneckenleithner, C., Warsch, W., Scheicher, R., Ott, R.G., Schäfer, M., Fajmann, S., Schlederer, M., Schiefer, A.-I., Reichart, U., Mayerhofer, M., Hoeller, C., Zöchbauer-Müller, S., Kerjaschki, D., Bock, C., Kenner, L., Hoefler, G., Freissmuth, M., Green, A.R., Moriggl, R., Busslinger, M., Malumbres, M. and Sexl, V. (2013) A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell 24, 167-181. [PMID:23948297][Full text]

Kim, J.A., Aberg, C., de Cárcer, G., Malumbres, M., Salvati, A. and Dawson, K.A. (2013) Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest. ACS Nano 7, 7483-7494. [PMID:23941353][Full text]

Doménech, E. and Malumbres, M. (2013) Mitosis-targeting therapies: a troubleshooting guide. Curr. Opin. Pharmacol. 13, 519-528. [PMID:23583638][Full text]

Trakala, M., Fernández-Miranda, G., Pérez de Castro, I., Heeschen, C. and Malumbres, M. (2013) Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1. Cell Cycle 12, 1030-1041. [PMID:23428904][Full text]

González-Gugel, E., Villa-Morales, M., Santos, J., Bueno, M.J., Malumbres, M., Rodríguez-Pinilla, S.M., Piris, M.A. and Fernández-Piqueras, J. (2013) Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development. Carcinogenesis 34, 902-908. [PMID:23288923][Full text]

Michel, C.I. and Malumbres, M. (2013) microRNA-203: tumor suppression and beyond. microRNA 2, 118-126. [PMID:25070781][Full text]

Parrillas, V., Martínez-Muñoz, L., Holgado, B.L., Kumar, A., Cascio, G., Lucas, P., Rodríguez-Frade, J.M., Malumbres, M., Carrera, A.C., van Wely, K.H., Mellado, M. (2013) Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells. Cell. Mol. Life Sci. 70, 545-558. [PMID:23001011][Full text]

Malumbres, M. (2013) miRNAs and cancer: An epigenetics view. Mol. Aspects Med. 34, 863-874. [PMID:22771542][Full text]

2012

Pérez de Castro, I. and Malumbres, M. (2012) Mitotic stress and chromosomal instability in cancer: the case for TPX2. Genes & Cancer 3, 721-730. [PMID:23634259][Full text]

Pick, J.E., Malumbres, M. & Klann, E. (2012) The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice. Learning & Memory 20, 11-20. [PMID:23242419][Full text]

Elorza, A., Soro-Arnáiz, I., Meléndez-Rodríguez, F., Rodríguez-Vaello, V., Marsboom, G., de Cárcer, G., Acosta-Iborra, B., Albacete-Albacete, L., Ordóñez, A., Serrano-Oviedo, L., Giménez-Bachs, J.M., Vara-Vega, A., Salinas, A., Sánchez-Prieto, R., Martín del Río, R., Sánchez-Madrid, F., Malumbres, M., Landázuri, M.O., Aragonés, J. (2012) HIF2a acts as an mTORC1 activator through the amino acid carrier SLC7A5. Mol. Cell 48, 681-691. [PMID:23103253][Full text]

Malumbres, M. (2012) Cell cycle-based therapies move forward. Cancer Cell 22, 419-420. [PMID:23079651][Full text]

de Cárcer, G., Pérez de Castro, I. and Malumbres, M. (2012) Inhibiting cell cycle kinases in cancer therapy. Front. Med. Chem. 6, 154-188. [Full text]

Malumbres, M. (2012) miRNAs versus oncogenes: the power of social networking. Mol. Syst. Biol. 8, 569. [PMID:22333973][Full text]

Aguirre-Portolés, A., Bird, A.W., Hyman, A., Cañamero, M., Pérez de Castro, I. and Malumbres, M. (2012) Tpx2 controls spindle integrity, genome stability and tumor development. Cancer Res. 72, 1518-1528. [PMID:22266221][Full text]

Manchado, E., Guillamot, M. and Malumbres, M. (2012) Killing cells by targeting mitosis. Cell Death Differ. 19, 369-377. [PMID:22223105][Full text]

2011

Guillamot, M., Manchado, E., Chiesa, M., Gómez-López, G., Pisano, D.G., Sacristán, M. and Malumbres, M. (2011) Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. Sci. Reports 1, 189. [PMID:22355704][Full text]

Wan, L., Zou, W., Gao, D., Inuzuka, Fukushima, H., Berg, A.H., Drapp, R., Shaik, S., Hu, D., Lester, C., Eguren, M., Malumbres, M., Glimcher, L.H. and Wei, W. (2011) Cdh1 Regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol. Cell 44, 721-733. [PMID:22152476][Full text]

Santamaría, D. and Malumbres, M. (2011) Tumor suppression by Spinophilin. Cell Cycle 10, 2831-2832. [PMID:21869595][Full text]

Malumbres, M. (2011) Physiological relevance of cell cycle kinases. Physiol. Rev. 91, 973-1007. [PMID:21742793][Full text]

Malumbres, M. (2011) Oncogene-induced mitotic stress: p53 and pRb get Mad too. Cancer Cell 19, 691-692. [PMID:21665141][Full text]

de Cárcer, G., Manning, G. and Malumbres, M. (2011) From Plk1 to Plk5: functional evolution of Polo-like kinases. Cell Cycle 10, 2255-2262. [PMID:21654194][Full text]

Fernández-Miranda, G., Trakala, M., Martín, J., Escobar, B., González, A., Ghyselinck, N.B., Ortega, S., Cañamero, M., Pérez de Castro, I. and Malumbres, M. (2011) Genetic disruption of Aurora B uncovers an essential role for Aurora C during early mammalian development. Development 138, 2661-2672. [PMID:21613325][Full text]

Chiesa, M.,* Guillamot, M.,* Bueno, M.J. and Malumbres, M. (2011) The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway. Cell Cycle 10, 1607-1617. [PMID:21502810][Full text]

Bueno, M.J., Gómez de Cedrón, M., Gómez-López, G., Pérez de Castro, I., di Lisio, L., Montes, S., Martínez, N., Guerrero, M., Sánchez, R., Santos, J., Pisano, D.G., Piris, M.A., Fernández-Piqueras, J. and Malumbres, M. (2011) Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway. Blood 117, 6255-6266. [PMID:21478429][Full text]

Eguren, M., Manchado, E. and Malumbres, M. (2011) Non-mitotic functions of the Anaphase-Promoting Complex. Semin. Cell Dev. Biol. 22, 572-578. [PMID:21439391][Full text]

Manchado, E. and Malumbres, M. (2011) Targeting aneuploidy for cancer therapy. Cell 144, 465-466. [PMID:21335229][Full text]

Bueno, M.J. and Malumbres, M. (2011) microRNAs and the cell cycle. Biochim. Biophys. Acta 1812, 592-601. [PMID:21315819][Full text]

Kollmann, K., Heller, G., Ott, R.G., Scheicher, R., Zebedin-Brandl, E., Schneckenleithner, C., Simma, O., Warsch, W., Eckelhart, E., Hoelbl, A., Bilban, M., Zöchbauer-Müller, S., Malumbres, M. and Sexl, V. (2011) C-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5’ region of Cdk6. Blood 117, 4065-4075. [PMID:21300982][Full text]

de Cárcer, G., Escobar, B., Higuero, A., García, L., Ansón, A., Pérez, G., Mollejo, M., Manning, G., Melendez, B., Abad-Rodriguez, J. and Malumbres, M. (2011) Plk5, a Polo-box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol. Cell. Biol. 31, 1225-1239. [PMID:21245385][Full text]

Song, M.S., Carracedo, A., Salmena, L., Song, S.J., Egia, A., Malumbres, M. and Pandolfi, P.P. (2011) Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144, 187-199. [PMID:21241890][Full text]

Pérez de Castro, I., Aguirre-Portolés, C., Martin, B., Fernández-Miranda, G., Klotzbucher, A., Kubbutat, M.H.G., Megías, D., Arlot-Bonnemains, Y. and Malumbres, M. (2011) A SUMOylation Motif in Aurora-A: Implications in Spindle Dynamics and Oncogenesis. Front. Oncol. 1, 50. [PMID:22649767][Full text]

Muñoz, I.G., Yébenes, H., Zhou, M., Mesa, P., Serna, M., Park, A.Y., Bragado-Nilsson, E., Beloso, A., de Cárcer, G., Malumbres, M., Robinson, C.V., Valpuesta, J.M. and Montoya, G. (2011) Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin. Nat. Struct. Mol. Biol. 18, 14-19. [PMID:21151115][Full text]

2010

Manchado, E., Guillamot, M., de Cárcer, G., Eguren, M., Trickey, M., García-Higuera, I., Moreno, S., Yamano, H., Cañamero, M. and Malumbres, M. (2010) Targeting mitotic exit leads to tumor regression in vivo: modulation by Cdk1, Mastl, and the PP2A/B55a,d phosphatase. Cancer Cell 18, 641-654. [PMID:21156286][Full text]

Santibanez, J.F., Pérez-Gómez, E., Fernandez-L, A., Garrido-Martín, E., Carnero, A., Malumbres, M., Vary, C.P.H., Quintanilla, M. and Bernabéu, C. (2010) The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras. Carcinogenesis 31, 2145-2154. [PMID:20884686][Full text]

Escobar, B., de Cárcer, G., Fernández-Miranda, G., Cascón, A., Bravo-Cordero, J.J., Montoya, M.C., Robledo, M., Cañamero, M. and Malumbres, M. (2010) Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation. Cancer Res. 70, 9349-9359. [PMID:20861187][Full text]

Fernández-Miranda, G., Pérez de Castro, I., Carmena, M., Aguirre-Portolés, C., Ruchaud, S., Fant, X., Montoya, G., Earnshaw, W.C. and Malumbres, M. (2010) Modulation of Aurora B function by SUMOylation. J. Cell Sci. 123, 2823-2833. [PMID:20663916][Full text]

Mourón, S., de Cárcer, G., Seco, E., Fernández-Miranda, G., Malumbres, M. and Nebreda, A.R.  (2010) RINGO/Speedy C is required to sustain the spindle assembly checkpoint. J. Cell Sci. 123, 2586-2595. [PMID:20605920][Full text]

Bueno, M.J., Gómez de Cedrón, M., Laresgoiti, U., Fernández-Piqueras, J., Zubiaga, A. and Malumbres, M. (2010) Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signalling. Mol. Cell. Biol. 30, 2983-2995. [PMID:20404092][Full text]

Manchado, E., Eguren, M. and Malumbres, M. (2010) The anaphase promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions. Biochem. Soc. Trans. 38, 65-71. [PMID:20074037][Full text]

Gurden, M.D.J., Holland, A.J., van Zon, W., Tighe, A., Vergnolle, M.A., Andres, D.A., Spielmann, H.P., Malumbres, M., Wolthuis, R.M.F., Cleveland, D.W. and Taylor, S.S. (2010) Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J. Cell. Sci. 123, 321-330. [PMID:20053638][Full text]

2009

Malumbres, M.,* Edward Harlow, Tim Hunt, Tony Hunter, Jill M. Lahti, Gerard Manning, David O. Morgan, Li-Huei Tsai, and Debra J. Wolgemuth (2009) Cyclin-dependent kinases: a family portrait. Nat. Cell Biol. 11, 1275-1276. [*Corresponding author] [PMID:19884882][Full text]

Garcia-Lavandeira, M.,  Quereda, V., Flores, I., Saez, C., Diaz-Rodriguez, E., Japon, M.A., Ryan, A.K., Blasco, M.A., Dieguez, C., Malumbres, M.* and Alvarez, C.V.* (2009) A GRFa2/Prop1/Stem (GPS) Cell Niche in the Pituitary. PLoS One 4, e4815. [* Co-corresponding authors] [PMID:19283075][Full text]

Malumbres, M. and Barbacid, M. (2009) Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev Cancer 9, 153-166. [PMID:19238148][Full text]

Muñoz, P., Blanco, R., de Carcer, R., Schoeftner, S., Benetti, R., Flores, J.M., Malumbres, M. and Blasco, M.A. (2009) TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol. Cell. Biol. 29, 1608-1625. [PMID:19124610][Full text]

Quereda, V., and Malumbres, M. (2009) Cell Cycle Control of Pituitary Development and Disease. J. Mol. Endocrinol. 42, 75-86. [PMID:18987159][Full text]

2008

Infante, A., Laresgoiti, U., Fernández-Rueda, J., Fullaondo, A., Galán, J., Díaz-Uriarte, R., Malumbres, M., Field, S.J. and Zubiaga, A.M. (2008) E2F2 Represses Cell Cycle Regulators to Maintain Quiescence. Cell Cycle 7, 3915-3927. [PMID:19066456][Full text]

Bueno, M.J., Pérez de Castro, I. and Malumbres, M. (2008). Control of cell proliferation pathways by microRNAs. Cell Cycle 7, 3143-3148. [PMID:18843198][Full text]

Pérez de Castro, I., de Cárcer, G., Montoya, G. and Malumbres, M. (2008) Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Curr. Opin. Pharmacol. 8, 375-383. [PMID:18644252][Full text]

García-Higuera, I., Manchado, E., Dubus, P., Cañamero, M., Mendez, J., Moreno, S. and Malumbres, M. (2008) Genomic Stability and Tumor Suppression by the APC/C Cofactor Cdh1. Nat. Cell Biol. 10, 802-811. [PMID:18552834][Full text]

Bueno, M.J., Pérez de Castro, I., Gómez de Cedrón, M., Santos, J., Calin, G.A., Cigudosa, J.C., Croce, C.M., Fernández-Piqueras, J. and Malumbres, M. (2008) Genetic and Epigenetic Silencing of microRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression. Cancer Cell 13, 496-506. [PMID:18538733][Full text]

Malumbres, M., Pevarello, P., Barbacid, M. and Bischoff, J.R. (2008) CDK inhibitors in cancer therapy: What is next? Trends Pharmacol Sci. 29, 16-21. [PMID:18054800][Full text]

2007

Malumbres, M. (2007) Cyclins and related kinases in cancer cells. J. BUON 12, S45-S52. [PMID:17935277]

Santamaría, D., Barrière, C., Cerqueira, A., Hunt, S.L., Tardy, C., Newton, K., Cáceres, J.F., Dubus, P., Malumbres, M. and Barbacid, M. (2007) Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448, 811-815. [PMID:17700700][Full text]

Malumbres, M. (2007) Cyclin-dependent kinases and their regulators as potential targets for anticancer therapeutics. In: Principles of Molecular Oncology, Bronchud, ed. Humana Press, pp. 204-235.[Full text]

Quereda, V., Martinalbo, J., Dubus, P., Carnero, A. and Malumbres, M. (2007) Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene 26, 7665-7674. [PMID:17599058][Full text]

Barrière, C., Santamaría, D., Cerqueira, A., Galán, J., Martín, A., Ortega, S., Malumbres, M., Dubus, P. and Barbacid, M. (2007) Mice thrive without Cdk4 and Cdk2. Mol. Oncol. 1, 72-83. [PMID:19383288][Full text]

de Cárcer, G.; Pérez de Castro, I. and Malumbres, M. (2007) Targeting cell cycle kinases for cancer therapy. Curr. Med. Chem. 14, 969-985. [PMID:17439397][Full text]

Cascón, A.,* Escobar, B.,* Montero-Conde, C., Rodríguez-Antona, C., Ruiz-Llorente, S., Osorio, A., Mercadillo, F., Letón, R., de Campos, J.M., García-Sagredo, J.M., Benítez, J., Malumbres, M. and Robledo, M. (2007) Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients. Hum. Mutat. 28, 613-621. [* Co-corresponding authors]. [PMID:17311301][Full text]

Pérez de Castro, I., de Cárcer, G. and Malumbres, M. (2007) A census of mitotic cancer genes. New insights into tumor cell biology and cancer therapy. Carcinogenesis 28, 899-912. [PMID:17259655][Full text]

Malumbres, M. and Barbacid, M. (2007) Cell cycle kinases in cancer. Curr. Opin. Genet. Dev. 17, 60-65. [PMID:17208431][Full text]

2006

Malumbres, M. (2006) Preclinical models for cell cycle-targeted therapies. Adv. Exp. Med. Biol. 587, 139-147. [PMID:17163163][Full text]

Blazquez, C., Carracedo, A., Barrado, L., Real, P.J., Fernández-Luna, J.L., Velasco, G., Malumbres, M. and Guzman, M. (2006) Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J. 20, 2633-2635. [PMID:17065222][Full text]

Tormo, D., Ferrer, A., Gaffal, E., Wenzel, J., Basner-Tschakarjan, E., Steitz, J., Heukamp, L.C., Gutgemann, I., Buettner, R., Malumbres, M., Barbacid, M., Merlino, G., Tuting, T. (2006). Rapid Growth of Invasive Metastatic Melanoma in Carcinogen-Treated Hepatocyte Growth Factor/Scatter Factor-Transgenic Mice Carrying an Oncogenic CDK4 Mutation. Am. J. Pathol. 169, 665-672. [PMID:16877364][Full text]

Malumbres, M. (2006) Therapeutic opportunities to control tumor cell cycles. Clin. Transl. Oncol. 8, 399-408. [PMID:16790392][Full text]

Hacker, E., Muller, H.K., Irwin, N., Gabrielli, B., Lincoln, D., Pavey, S., Powell, M.B., Malumbres, M., Barbacid, M., Hayward, N. and Walker, G. (2006) Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Res. 66, 2946-2952. [PMID:16540642][Full text]

Malumbres, M. and Barbacid, M. (2006) Is Cyclin D1/Cdk4 kinase a bona-fide cancer target? Cancer Cell 9, 2-4. [PMID:16413464][Full text]

Malumbres, M., Dubus, P. and Ortega, S. (2006) Mouse models to study the in vivo function of Cyclin-dependent kinases in normal homeostasis and tumor development. In: Inhibitors of cyclin-dependent kinases as anti-tumor agents (Smith, P.J. and Yue, E.W., eds.) CRC Press, Boca Raton. pp. 55-83.[Full text]

Duensing, A., Liu, Y., Tseng, M., Malumbres, M., Barbacid, M. and Duesing, S. (2006) Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene 25, 2943-2949. [PMID:16331279][Full text]

Steitz, J., Büchs, S., Tormo, D., Ferrer, A., Wenzel, J., Huber, C., Wölfel, T., Barbacid, M., Malumbres, M. and Tüting, T. (2006) Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin. Int. J. Cancer 118, 373-380. [PMID:16049960][Full text]

2005

Malumbres, M. and Barbacid, M. (2005) Mammalian cyclin-dependent kinases. Trends Biochem. Sci., 30, 630-641. [PMID:16236519][Full text]

Barbacid, M., Ortega, S., Sotillo, R., Odajima, J., Martín, A., Santamaría, D., Dubus, P. and Malumbres, M. (2005) Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases. Cold Spring Harb. Symp. Quant. Biol. 70, 233-240. [Full text]

Abella, A., Dubus, P., Malumbres, M., Rane, S.G., Kiyokawa, H., Sicard, A., Vignon, F., Langin, D., Barbacid, M. and Fajas, L. (2005) Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metabolism 2, 239-249. [PMID:16213226][Full text]

Martín, A., Odajima, J., Hunt, S.L., Dubus, P., Ortega, S., Malumbres, M.* and Barbacid, M.* (2005) Cell Cycle Inhibition and Tumor Suppression by p21Cip1 and p27Kip1 are Independent of Cdk2. Cancer Cell 7, 591-598. [*Co-corresponding authors] [PMID:15950907][Full text]

Sotillo, R., Renner, O., Dubus, P., Ruiz-Cabello, J., Martín-Caballero, J., Barbacid, M., Carnero, A. and Malumbres, M. (2005) Cooperation Between Cdk4 and p27Kip1 in Tumor Development: a Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity. Cancer Res. 65, 3846-3852. [PMID:15867383][Full text]

Pérez de Castro, I., Benet, M., Jiménez, M., Alzabin, S., Malumbres, M. and Pellicer, A. (2005) Mouse p10, an alternative spliced form of p15INK4b, inhibits cell cycle progression and malignant transformation. Cancer Res. 65, 3249-3256. [PMID:15833857][Full text]

Malumbres, M. (2005) Revisiting the “Cdk-centric” view of the mammalian cell cycle. Cell Cycle 4, 206-210. [PMID:15655365][Full text]

Doctoral Thesis

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