The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner

A cellcycle kinase-phosphatase module – MASTL/Greatwall & PP2A-B55 – restrains PI3K-Akt activity in an mTORC1-dependent manner to prevent excessive signaling. The AKT-mTOR pathway is a central regulator of cell growth and metabolism. Upon sustained mTOR activity,...

What is the role of mammalian homologs of key yeast cell cycle phosphatase CDC14?

CDC14A/B control pluripotent cells exit from stemness to allow neural differentiation in mice Maintenance of stemness is tightly linked to cell cycle regulation through protein phosphorylation by cyclin-dependent kinases (CDKs). However, how this process is reversed...

Unique case of woman who survived 12 tumors may help improve cancer diagnosis

The exceptional case of a person who has survived twelve tumours opens up new avenues for early diagnosis and immunotherapy in cancer by Dra. Carolina Villarroya, postdoctoral researcher at Malumbres Lab. Germline mutations leading to aneuploidy are rare, and their...

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International Day of Women and Girl in Science, 2020

International Day of Women and Girl in Science, 2020

International Day of Women and Girl in Science, 2020. This year, CaixaForum Madrid organised an event for the International Day of Women and Girls in Science, and our lab mate Maria was invited, representing the Innovative program of La Caixa Foundation...

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Unique case of woman who survived 12 tumors may help improve cancer diagnosis

Médicos y científicos identifican un nuevo síndrome causado por una mutación nunca vista en humanos que multiplica la aparición de células cancerosas

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Latest News in the Press

July 2020

Improving the quality of stem cells

July 2020

Improving the quality of stem cells

July 2020

Improving the quality of stem cells

July 2020

Improving the quality of stem cells

February 2020

Investigación que busca la cura de la diabetes

February 2019

Vida y esperanza más allá del cáncer

February 2019

La científica que quiere levantar un ‘match point’ al cáncer de mama

October 2018

Investigadores del CNIO descubren el origen de la trombocitopenia causada por un oncogen

September 2018

¿Hasta dónde puede llegar la técnica de edición genética CRISPR?

August 2018

Discovery of a new tumor suppressor previously thought to be an oncogene

August 2018

Descubren que un gen promotor del cáncer puede ayudar a frenarlo

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