Latest News
The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner
A cellcycle kinase-phosphatase module – MASTL/Greatwall & PP2A-B55 – restrains PI3K-Akt activity in an mTORC1-dependent manner to prevent excessive signaling. The AKT-mTOR pathway is a central regulator of cell growth and metabolism. Upon sustained mTOR activity,...
What is the role of mammalian homologs of key yeast cell cycle phosphatase CDC14?
CDC14A/B control pluripotent cells exit from stemness to allow neural differentiation in mice Maintenance of stemness is tightly linked to cell cycle regulation through protein phosphorylation by cyclin-dependent kinases (CDKs). However, how this process is reversed...
Unique case of woman who survived 12 tumors may help improve cancer diagnosis
The exceptional case of a person who has survived twelve tumours opens up new avenues for early diagnosis and immunotherapy in cancer by Dra. Carolina Villarroya, postdoctoral researcher at Malumbres Lab. Germline mutations leading to aneuploidy are rare, and their...
Dr. Rodrigo Sánchez Bayona awarded by Instituto de Salud Carlos III-Rio Hortega
Dr. Rodrigo Sánchez Bayona awarded by Instituto de Salud Carlos III to combine his work as a oncologist at the Breast Cancer Unit in Hosptial 12 de Octubre with clinic research at Cell Division and Cancer group.
Dr. Miguel Ruiz Torres, postdoctoral researcher at Malumbres Lab, awarded with an AECC Postdoctoral Fellowship 2021
Improving CDK4/6-targeted therapies in advanced breast cancer
Dr. Ruiz research will be focused in the design of new strategies to improve the current treatments in advance breast cancer. He will identify and characterize new therapeutic targets that will be combined with the current standard-of-care in metastatic breast cancer.
JCI Insight: Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias
Centrosomes are key organelles for Neural Progenitor homeostasis during development. Disruption of centrosome dynamics alters neurodevelopment in an array of genetically-engineered mice as seen in microcephaly patients Abstract Congenital microcephaly (MCPH)...
EMBO J: New technology to improve the use of stem cells in regenerative medicine
A new technology based on the transient exposure to a microRNA improves the potential of pluripotent cells in regenerative medicine
A new strategy to prevent the most aggressive tumours from generating resistance to chemotherapy
CDK4/6 inhibitors are effective in certain types of cancer because they stop the multiplication of tumour cells, but they cannot be used together with chemotherapy since chemotherapy only acts against cancer cells that are actively multiplying We changed this approach...
International Day of Women and Girl in Science, 2020
International Day of Women and Girl in Science, 2020. This year, CaixaForum Madrid organised an event for the International Day of Women and Girls in Science, and our lab mate Maria was invited, representing the Innovative program of La Caixa Foundation...
A novel microRNA-based strategy to expand the differentiation potency of stem cells
We have discovered a yet-unknown and exciting application of a microRNA: transiently applied to Stem Cells (SCs; either pluripotent or adult SCs), this miRNA significantly improves their differentiation potential. Our data show that a brief exposure to the miRNA...
Unique case of woman who survived 12 tumors may help improve cancer diagnosis
Médicos y científicos identifican un nuevo síndrome causado por una mutación nunca vista en humanos que multiplica la aparición de células cancerosas
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Latest News in the Press
July 2020
Improving the quality of stem cells
July 2020
Improving the quality of stem cells
July 2020
Improving the quality of stem cells
July 2020
Improving the quality of stem cells
February 2020
Investigación que busca la cura de la diabetes
February 2019
Vida y esperanza más allá del cáncer
February 2019
La científica que quiere levantar un ‘match point’ al cáncer de mama
October 2018
Investigadores del CNIO descubren el origen de la trombocitopenia causada por un oncogen
September 2018
¿Hasta dónde puede llegar la técnica de edición genética CRISPR?
August 2018
Discovery of a new tumor suppressor previously thought to be an oncogene
August 2018