Nov 17, 2022
A cellcycle kinase-phosphatase module – MASTL/Greatwall & PP2A-B55 – restrains PI3K-Akt activity in an mTORC1-dependent manner to prevent excessive signaling. The AKT-mTOR pathway is a central regulator of cell growth and metabolism. Upon sustained mTOR activity,...
Nov 10, 2022
CDC14A/B control pluripotent cells exit from stemness to allow neural differentiation in mice Maintenance of stemness is tightly linked to cell cycle regulation through protein phosphorylation by cyclin-dependent kinases (CDKs). However, how this process is reversed...
Nov 10, 2022
The exceptional case of a person who has survived twelve tumours opens up new avenues for early diagnosis and immunotherapy in cancer by Dra. Carolina Villarroya, postdoctoral researcher at Malumbres Lab. Germline mutations leading to aneuploidy are rare, and their...
Jul 15, 2020
JCI Insight: Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias November, 2021 Centrosomes are key organelles for Neural Progenitor homeostasis during development. Disruption of centrosome...
Nov 5, 2019
We have discovered a yet-unknown and exciting application of a microRNA: transiently applied to Stem Cells (SCs; either pluripotent or adult SCs), this miRNA significantly improves their differentiation potential. Our data show that a brief exposure to the miRNA...
