Cell Division and Cancer






Lab members

Lab. pictures




Publications (since 2004)



2016 - 2015 - 2014 - 2013 - 2012 - 2011 - 2010 - 2009 - 2008 - 2007 - 2006 - 2005 - 2004

Liu, J., Wan, L., Liu, J., Yuan, Z., Zhang, J., Guo, J., Malumbres, M., Liu, J., Zou, W. and Wei, W. (2016) Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner". Cell Discovery, in press.


Liu, J., Shao, R., Wan, L., Liu, J., Yan, G., Yuan, Z., Han, Y., Zou, W., Guo, J., Xu, Z., Liu, J., Malumbres, M. and Wei, W. (2016) Cdh1 Regulates Craniofacial Development in Part via APC-dependent Activation of Goosecoid. Cell Res., in press.

  122 Blas-Rus, N., Bustos-Morán, E., Pérez de Castro, I., de Cárcer, G., Borroto, A., Camafeita, E., Jorge, I., Alarcón, B., Malumbres, M., Martín-Cófreces, N.B. and Sánchez-Madrid, F. (2016) Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat. Commun. 7, 11389. Doi: 10.1038/ncomms11389 PMID: 27091106
  121 Hydbring, P., Malumbres, M. and Sicinski, P. (2016) Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nat. Rev. Mol. Cell. Biol., in press.

PMID: 27033256

  120 Malumbres, M. (2016) CDK4/6 inhibitors resTORe therapeutic sensitivity in HER2+ breast cancer. Cancer Cell 29, 243-244. PMID: 26977873
  119 Mitxelena, J., Apraiz, A., Vallejo, J., Malumbres, M. and Zubiaga, A. (2016) E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Nucleic Acids Res., in press. PMID: 26961310
  118 Sobecki, M., Mrouj, K., Camasses, A., Parisis, N., Nicolas, E., Llères, D., Gerbe, F., Prieto, S., Krasinska, L., David, A., Eguren, M., Birling, M.-C., Urbach, S., Hem, S., Déjardin, J., Malumbres, M., Jay, P., Dulic, V., Lafontaine, D.L.J., Feil, R.P. and Fisher, D. (2016) The cell proliferation antigen Ki-67 organises heterochromatin. eLife, in press. PMID: 26949251
  117 Correia, N.C., Melão, A., Póvoa, V., Sarmento, L., Gómez de Cedrón, M., Malumbres, M., Enguita, F.J. and Barata, J.T. (2106) microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. Oncotarget, in press. PMID: 26882564

Quereda, V., Porlan, E., Cañamero, M., Dubus, P. and Malumbres, M. (2015) An essential role for Ink4 and Cip/Kip Cell Cycle Inhibitors in Preventing Replicative Stress. Cell Death Differ. 23, 430-441..

 PMID: 26292757 

  115 Búa, S., Sotiropoulou, P., Sgarlata, C., Borlado, L.R., Eguren, M., Domínguez, O., Ortega, S., Malumbres, M., Blanpain, C. and Méndez, J. (2015) Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle. Cell Cycle 14, 3897-3907 PMID: 26697840
  114 Malumbres, M. (2015) Keeping order in anaphase. Dev Cell, 35, 403-404. PMID: 26609955
  113 Esteban-Martínez, L., Doménech, E., Boya, P. Salazar-Roa, M. and Malumbres, M. (2015) Mitophagy in mitosis: more than a myth. Autophagy 11, 2379-2380. PMID: 26565111
  112 Sánchez-Martínez, R., Gómez de Cedrón, M., Vargas, T., Molina, S., García, B., Herranz, J., Álvarez-Fernández, M., Moreno-Rubio, J., Reglero, G., Pérez-Moreno, M., Feliú, J., Malumbres, M., Rámirez de Molina, A. (2015) A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy. Oncotarget 6, 38719-38736. PMID: 26451612

Doménech, E., Maestre, C., Esteban-Martínez, L., Partida, D., Pascual, R., Fernández-Miranda, G., Seco, E., Campos-Olivas, R., Pérez, M., Megias, D., Allen, K., López, M., Saha, A.K., Velasco, G., Rial, E., Méndez, R., Boya, P., Salazar-Roa, M. and Malumbres, M. (2015) AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat. Cell Biol. 17, 1304-1316.

 PMID: 26322680  


González-Loyola, A., Fernández-Miranda, G., Trakala, M., Partida, D., Samejima, K., Ogawa, H., Cañamero, M., de Martino, A., Martínez-Ramírez, A., de Cárcer, G., Pérez de Castro, I., Earnshaw, W.C. and Malumbres, M. (2015) Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development. Mol. Cell. Biol. 35, 3566-3578.

 PMID: 26240282  


Serra, H., Chivite, I., Angulo-Urarte, A., Soler, A., Sutherland, J.D., Arruabarrena-Aristorena, A., Ragab, A., Lim, R., Malumbres, M., Fruttiger, M., Potente, M., Serrano, M., Fabra, A., Viñals, F., Casanovas, O., Pandolfi, P.P., Bigas, A., Carracedo, A., Gerhardt, H. and Graupera, M. (2015) PTEN mediates Notch-dependent stalk cell arrest in angiogenesis. Nat. Commun., 6, 7935.

 PMID: 26228240  


Trakala, M., Partida, P., Salazar-Roa, M., Maroto, M., Wachowicz, P. de Cárcer, G. and Malumbres, M. (2015). Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice. Blood 126, 1707-1714.

 PMID: 26185128  


Álvarez-Fernández, M. and Malumbres, M. (2015) An atypical oncogene within the atypical E2Fs. J. Natl. Cancer Inst., 107, xxx. Jun 18;107(9). Print 2015 Sep.

 PMID: 26089542  


Huang J, Ikeuchi Y, Malumbres M, Bonni A. (2015) A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain. Neuron 86, 726-739.

 PMID: 25913861  


Penas C, Govek EE, Fang Y, Ramachandran V, Daniel M, Wang W, Maloof ME, Rahaim RJ, Bibian M, Kawauchi D, Finkelstein D, Han JL, Long J, Li B, Robbins DJ, Malumbres M, Roussel MF, Roush WR, Hatten ME, Ayad NG. (2015) Casein Kinase 1δ Is an APC/C(Cdh1) Substrate that Regulates Cerebellar Granule Cell Neurogenesis. Cell Reports 11, 249-260.

 PMID: 25843713


Trakala M, Rodríguez-Acebes S, Maroto M, Symonds CE, Santamaría D, Ortega S, Barbacid M, Méndez J, Malumbres M. (2015) Functional reprogramming of polyploidization in megakaryocytes. Dev. Cell. 32, 155-167.

PMID: 25625205


Scheicher, R., Hoelbl-Kovacic, A., Bellutti, F., Tigan, A.S., Prchal-Murphy, M., Heller, G., Schneckenleithner, C., Salazar-Roa, M., Zoechbauer-Mueller, S., Zuber, J., Malumbres, M., Kollmann, K. and Sexl, V. (2015) CDK6 as a key regulator of hematopoietic and leukemic stem cell activation. Blood 125, 90-101.

PMID: 25342715


Trakala, M. and Malumbres, M. (2014) Cyclin C surprises in tumor suppression. Nat. Cell Biol. 16, 1031-1033

PMID: 25358351


Valcárcel, J. and Malumbres, M. (2014) Splicing together sister chromatids. EMBO J. 33, 2601-2603

PMID: 25266476


Malumbres, M. and Pérez de Castro, I. (2014) Aurora kinase A inhibitors: promising agents in anti-tumoral therapy. Expert Opin. Ther. Targets 18, 1377-1393

PMID: 25200357


Rodríguez-Díez, E., Quereda, V., Bellutti, F., Prchal-Murphy, M., Partida, D., Eguren, M., Gómez de Cedrón, M., Dubus, P., Cañamero, M., Martínez, L., Sexl, V. and Malumbres, M. (2014) Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis. Blood 124, 2380-2390

PMID: 25157181


Malumbres, M. (2014) Cyclin-dependent kinases. Genome Biol. 15, 122



Piazzolla, D., Palla, A.R., Pantoja, C., Cañamero, M., Pérez de Castro, I., Ortega, S., Gómez-López, G., Dominguez, O., Megías, D., Roncador, G., Luque-Garcia, J.L., Fernandez-Tresguerres, B., Fernandez, A.F., Fraga, M.F., Rodriguez-Justo, M., Manzanares, M., Sánchez-Carbayo, M., García-Pedrero, J.M., Rodrigo, J.P., Malumbres, M. and Serrano, M. (2014) Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat. Commun. 5, 4226.

PMID: 24979572


Wang, P., Malumbres, M. and Archambault, V. (2014) The Greatwall-PP2A Axis in Cell Cycle Control. Methods in Mol. Biol. 1170, 99-111.

PMID: 24906311


Álvarez-Fernández, M. and Malumbres, M. (2014) Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry. Bioessays 36, 757-765.

PMID: 24889070


Porlan, E., Martí-Prado, B., Morante-Redolat, J.M., Consiglio, A., Delgado, A.C., Kypta, R., López-Otín, C., Kirstein, M. and Fariñas, I. (2014)  MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin. Nat, Cell Biol. 16, 629-638.

PMID: 24952463


de Cárcer, G. and Malumbres, M. (2014) A centrosomal route for cancer genome instability. Nat. Cell Biol. 16, 504-506.

PMID: 24875738


Wan, L., Tan, M., Yang, J., Inuzuka, H., Dai, X., Wu, T., Liu, J., Shaik, S., Chen, G., Deng, J., Malumbres, M., Letai, A., Kirschner, M.W., Sun, Y., Wei, W. (2014) APC(Cdc20) Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction. Dev Cell. 29, 377-391.

PMID: 24871945


Rattani, A., Vinod, P.K., Godwin, J., Tachibana-Konwalski, K., Wolna, M., Malumbres, M., Novák, B. and Nasmyth, K. (2014) Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible. Curr Biol. 24, 630-637.

PMID: 24583015


Eguren, M., Alvarez-Fernandez, M., García, F., Lopez-Contreras, A., Fujimitsu, K., Yaguchi, H., Luque-Garcia, J.L., Fernandez-Capetillo, O., Muñoz, J., Yamano, H. and Malumbres, M. (2014). A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens. Cell Reports 6, 670-683.

PMID: 24508461


Trakala, M., Malumbres, M. (2014) The functional relevance of polyploidization in the skin. Exp Dermatol. 23, 92-93.

PMID: 24330335


Malumbres, M. (2014) Control of the cell cycle. In: Abeloff’s Clinical Oncology, 5th edition. (Niederhuber, J.E., Armitage, J.O., Doroshow, J.H., Kastan, M.B., and Tepper, J., eds.) Elsevier, pp. 52-68.




Eguren, M, Porlan, E., Manchado, E., García-Higuera, I., Cañamero, M., Fariñas, I. and Malumbres, M. (2013) The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat. Commun., 13). DOI:10.1038/ncomms3.

PMID: 24301385

Pérez de Castro I.,  Aguirre-Portolés C., Fernández-Miranda G., Cañamero M., Cowley D.O., Van Dyke T.,  Malumbres M. (2013) Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res, 73, 6804. DOI: 10.1158/0008-5472.CAN-13-0586.

PMID: 24242071

Álvarez-Fernández, M., Sánchez-Martínez, R., Sanz-Castillo, B., Gan, P.P., Sanz-Flores, M., Trakala, M., Ruiz-Torres, M., Lorca, T., Castro., A. and Malumbres, M. (2013) Greatwall is essential to prevent mitotic collapse after nuclear envelop breakdown in mammals. Proc. Natl. Acad. Sci. USA., 110, 17374-9.

PMID: 24101512


Michel, C.I. and Malumbres, M. (2013) microRNA-203: tumor suppression and beyond. microRNA 2, 118-126.

PMID: 25070781


Frangini, A., Sjöberg, M., Román-Trufero, M., Dharmalingam, G., Haberle, V., Bartke, T., Lenhard, B.,  Malumbres, M., Vidal, M. and Dillon, N. (2013) The Aurora B kinase and the polycomb protein Ring1B combine to regulate active promoters in quiescent lymphocytes. Mol. Cell 51, 647-661.

PMID: 24034696

Kollmann, K., Heller, G., Schneckenleithner, C., Warsch, W., Scheicher, R., Ott, R.G., Schäfer, M., Fajmann, S., Schlederer, M., Schiefer, A.-I., Reichart, U., Mayerhofer, M., Hoeller, C., Zöchbauer-Müller, S., Kerjaschki, D., Bock, C., Kenner, L., Hoefler, G., Freissmuth, M., Green, A.R., Moriggl, R., Busslinger, M., Malumbres, M. and Sexl, V. (2013) A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell 24, 167-181.

PMID: 23948297]

Kim, J.A., Aberg, C., de Cárcer, G., Malumbres, M., Salvati, A. and Dawson, K.A. (2013) Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest. ACS Nano, 7, 7483–7494.

PMID: 23941353

Malumbres, M. (2013) Mitotic kinases. In: Encyclopedia of Systems Biology (Dubitzky, W., Wolkenhauer, O., Yokota, H. & Cho, K.H., eds), Springer, Heidelberg, in press. [ISBN 978-1-4419-9864-4]


Malumbres, M. (2013) Cyclins and Cyclin-dependent kinases. In: Encyclopedia of Systems Biology, (Dubitzky, W., Wolkenhauer, O., Yokota, H. & Cho, K.H., eds.), Springer, Heidelberg, in press. [ISBN 978-1-4419-9864-4]


Tuck, C., Zhang, T., Potapova, T., Malumbres, M. and Novák, B. (2013) Robust Mitotic Entry is ensured by a Latching Switch. Biol. Open., 2, 924-931


PMID: 24143279


Doménech, E. and Malumbres, M. (2013) Mitosis-targeting therapies: a troubleshooting guide. Curr. Opin. Pharmacol. 13, 519-528.

PMID: 23583638


Trakala, M., Fernández-Miranda, G., Pérez de Castro, I., Heeschen, C. and Malumbres, M. (2013) Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1. Cell Cycle 12, 1030-1041.

PMID: 23428904


Malumbres, M. (2012) miRNAs and cancer: An epigenetics view. Mol. Aspects Med. Jul 4. doi: 10.1016/j.mam.2012.06.005

PMID: 22771542


González-Gugel, E., Villa-Morales, M., Santos, J., Bueno, M.J., Malumbres, M., Rodríguez-Pinilla, S.M., Piris, M.A. and Fernández-Piqueras, J. (2013) Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development. Carcinogenesis 34, 902-908.

PMID: 23288923


Pick, J.E., Malumbres, M. & Klann, E. (2013) The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice. Learning & Memory 20, 11-20

PMID: 23242419


Parrillas, V., Martínez-Muñoz, L., Holgado, B.L., Kumar, A., Cascio, G., Lucas, P., Rodríguez-Frade, J.M., Malumbres, M., Carrera, A.C., van Wely, K.H., Mellado, M. (2013) Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells. Cell. Mol. Life Sci. 70, 545-558

PMID: 23001011




Pérez de Castro, I. and Malumbres, M. (2012) Mitotic stress and chromosomal instability in cancer: the case for TPX2. Genes & Cancer 3, 721-730.

PMID: 23634259

Malumbres, M. (2012) Cell cycle-based therapies move forward. Cancer Cell 22, 419-420.

PMID: 23079651

Pick, J., Malumbres, M. & Klann, E. (2012) The E3 Ligase APC/C-Cdh1 is Required for Associative Fear Memory and Long-term Potentiation in the Amygdala of Adult Mice. Learning & Memory 20, 11-20.

PMID: 23242419

Elorza, A., Soro-Arnáiz, I., Meléndez-Rodríguez, F., Rodríguez-Vaello, V., Marsboom, G., de Cárcer, G., Acosta-Iborra, B., Albacete-Albacete, L., Ordóñez, A., Serrano-Oviedo, L., Giménez-Bachs, J.M., Vara-Vega, A., Salinas, A., Sánchez-Prieto, R., Martín del Río, R., Sánchez-Madrid, F., Malumbres, M., Landázuri, M.O., Aragonés, J. (2012) HIF2a acts as an mTORC1 activator through the amino acid carrier SLC7A5. Mol. Cell 48, 681-691.

PMID: 23103253

Malumbres, M. (2012) miRNAs versus oncogenes: the power of social networking. Mol. Syst. Biol. 8, 569. doi: 10.1038/msb.2012.2

PMID: 22333973

Aguirre-Portolés, A., Bird, A.W., Hyman, A., Cañamero, M., Pérez de Castro, I. and Malumbres, M. (2012) Tpx2 controls spindle integrity, genome stability and tumor development. Cancer Res. 72, 1518-1528.

PMID: 22266221


Manchado, E., Guillamot, M. and Malumbres, M. (2012) Killing cells by targeting mitosis. Cell Death Differ., 19, 369-377. doi: 10.1038/cdd.2011.197 .

PMID: 22223105


de Cárcer, G., Pérez de Castro, I. and Malumbres, M. (2012) Inhibiting cell cycle kinases in cancer therapy. Front. Med. Chem. 6, 154-188.





Guillamot, M., Manchado, E., Chiesa, M., Gómez-López, G., Pisano, D.G., Sacristán, M. and Malumbres, M. (2011) Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. (Nature) Sci. Reports, in press

PMID: 22355704


Wan, L., Zou, W., Gao, D., Inuzuka, Fukushima, H., Berg, A.H., Drapp, R., Shaik, S., Hu, D., Lester, C., Eguren, M., Malumbres, M., Glimcher, L.H. and Wei, W. (2011) Cdh1 Regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol. Cell 44, 721-733.

PMID: 22152476

Pérez de Castro, I., Aguirre-Portolés, C., Martin, B., Fernández-Miranda, G., Klotzbucher, A., Kubbutat, M.H.G., Megías, D., Arlot-Bonnemains, Y. and Malumbres, M. (2011) A SUMOylation Motif in Aurora-A: Implications in Spindle Dynamics and Oncogenesis. Front. Oncol. 1, 50.

PMID: 22649767

Santamaría, D. and Malumbres, M. (2011) Tumor suppression by Spinophilin. Cell Cycle 10, 2831-2832.

PMID: 21869595


Malumbres, M. (2011) Physiological relevance of cell cycle kinases. Physiol. Rev. 91, 973-1007.

PMID: 21742793




de Cárcer, G., Manning, G. and Malumbres, M. (2011) From Plk1 to Plk5: functional evolution of Polo-like kinases. Cell Cycle 10, 2255-2262.

PMID: 21654194


Malumbres, M. (2011) Oncogene-induced mitotic stress: p53 and pRb get Mad too. Cancer Cell 19, 691-692.

PMID: 21665141


Fernández-Miranda, G., Trakala, M., Martín, J., Escobar, B., González, A., Ghyselinck, N.B., Ortega, S., Cañamero, M., Pérez de Castro, I. and Malumbres, M. (2011) Genetic disruption of Aurora B uncovers an essential role for Aurora C during early mammalian development. Development 138, 2661-2672.



Chiesa, M.,* Guillamot, M.,* Bueno, M.J. and Malumbres, M. (2011) The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway. Cell Cycle 10, 1607-1617.

             News and Views:

Wei, Z & Zhang, P. A phosphatase turns aggressive: The oncogenicity of Cdc14B. Cell Cycle 10, 2414-2415.

Visintin, R. Cdc14B: When a good kid turns bad. Cell Cycle 10, 2416-2417.

PMID: 21502810


Eguren, M., Manchado, E. and Malumbres, M. (2011) Non-mitotic functions of the Anaphase-Promoting Complex. Semin. Cell Dev. Biol., in press.

PMID: 21439391

Bueno, M.J., Gómez de Cedrón, M., Gómez-López, G., Pérez de Castro, I., di Lisio, L., Montes, S., Martínez, N., Guerrero, M., Sánchez, R., Santos, J., Pisano, D.G., Piris, M.A., Fernández-Piqueras, J. and Malumbres, M. (2011) Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway. Blood 117, 6255-6266.

PMID: 21478429

Manchado, E. and Malumbres, M. (2011) Targeting aneuploidy for cancer therapy. Cell 144, 465-466.

PMID: 21335229

Bueno, M.J. and Malumbres, M. (2011) microRNAs and the cell cycle. Biochim. Biophys. Acta 1812, 592-601.

PMID: 21315819

 Kollmann, K., Heller, G., Ott, R.G., Scheicher, R., Zebedin-Brandl, E., Schneckenleithner, C., Simma, O., Warsch, W., Eckelhart, E., Hoelbl, A., Bilban, M., Zöchbauer-Müller, S., Malumbres, M. and Sexl, V. (2011) C-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5’ region of Cdk6. Blood 117, 4065-4075.

PMID: 21300982

de Cárcer, G., Escobar, B., Higuero, A., García, L., Ansón, A., Pérez, G., Mollejo, M., Manning, G., Melendez, B., Abad-Rodriguez, J. and Malumbres, M. (2011) Plk5, a Polo-box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol. Cell. Biol. 31, 1225-1239.

Selected for Mol. Cell. Biol. Spotlights.

Extra-View in Cell Cycle 10 (2011)

Seleced by Targe Intelligence Service (https://www.targetintelligenceservice.com/main/public/case.jsp?report_id=44541)

PMID: 21245385

Song, M.S., Carracedo, A., Salmena, L., Song, S.J., Egia, A., Malumbres, M. and Pandolfi, P.P. (2011) Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144, 187-199.

PMID: 21241890

Muñoz, I.G., Yébenes, H., Zhou, M., Mesa, P., Serna, M., Park, A.Y., Bragado-Nilsson, E., Beloso, A., de Cárcer, G., Malumbres, M., Robinson, C.V., Valpuesta, J.M. and Montoya, G. (2011) Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin. Nat. Struct. Mol. Biol. 18, 14-19.

PMID: 21151115




Manchado, E., Guillamot, M., de Cárcer, G., Eguren, M., Trickey, M., García-Higuera, I., Moreno, S., Yamano, H., Cañamero, M. and Malumbres, M. (2010) Targeting mitotic exit leads to tumor regression in vivo: modulation by Cdk1, Mastl, and the PP2A/B55a,d phosphatase. Cancer Cell 18, 641-654.

PMID: 21156286

Santibanez, J.F., Pérez-Gómez, E., Fernandez-L, A., Garrido-Martín, E., Carnero, A., Malumbres, M., Vary, C.P.H., Quintanilla, M. and Bernabéu, C. (2010) The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras. Carcinogenesis 31, 2145-2154.

PMID: 20884686

Escobar, B.,* de Cárcer, G.,* Fernández-Miranda, G., Cascón, A., Bravo-Cordero, J.J., Montoya, M.C., Robledo, M., Cañamero, M. and Malumbres, M. (2010) Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation. Cancer Res. 70, 9349-9359. [* Co-corresponding authors].

PMID: 20861187

Fernández-Miranda, G., Pérez de Castro, I., Carmena, M., Aguirre-Portolés, C., Ruchaud, S., Fant, X., Montoya, G., Earnshaw, W.C. and Malumbres, M. (2010) Modulation of Aurora B function by SUMOylation. J. Cell Sci. 123, 2823-2833.

PMID: 20663916

 Mourón, S., de Cárcer, G., Seco, E., Fernández-Miranda, G., Malumbres, M. and Nebreda, A.R.  (2010) RINGO/Speedy C is required to sustain the spindle assembly checkpoint. J. Cell Sci. 123, 2586-2595.

PMID: 20605920

Bueno, M.J., Gómez de Cedrón, M., Laresgoiti, U., Fernández-Piqueras, J., Zubiaga, A. and Malumbres, M. (2010) Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signalling. Mol. Cell. Biol. 30, 2983-2995.

PMID: 20404092

Manchado, E., Eguren, M. and Malumbres, M. (2010) The anaphase promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions. Biochem. Soc. Trans. 38, 65-71.

PMID: 20074037

Gurden, M.D.J., Holland, A.J., van Zon, W., Tighe, A., Vergnolle, M.A., Andres, D.A., Spielmann, H.P., Malumbres, M., Wolthuis, R.M.F., Cleveland, D.W. and Taylor, S.S. (2010) Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J. Cell. Sci. 123, 321-330.

PMID: 20053638




Malumbres, M.,* Edward Harlow, Tim Hunt, Tony Hunter, Jill M. Lahti, Gerard Manning, David O. Morgan, Li-Huei Tsai, and Debra J. Wolgemuth (2009) Cyclin-dependent kinases: a family portrait. Nat. Cell Biol. 11, 1275-1276. [*Corresponding author]

PMID: 19884882

Garcia-Lavandeira, M.,  Quereda, V., Flores, I., Saez, C., Diaz-Rodriguez, E., Japon, M.A., Ryan, A.K., Blasco, M.A., Dieguez, C., Malumbres, M.* and Alvarez, C.V.* (2009) A GRFa2/Prop1/Stem (GPS) Cell Niche in the Pituitary. PLoS One 4, e4815. [* Co-corresponding authors].

PMID: 19283075
TOP 1/1000th

Malumbres, M. and Barbacid, M. (2009) Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev Cancer 9, 153-166.

PMID: 19238148

Muñoz, P., Blanco, R., de Carcer, R., Schoeftner, S., Benetti, R., Flores, J.M., Malumbres, M. and Blasco, M.A. (2009) TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol. Cell. Biol. 29, 1608-1625.

PMID: 19124610

Quereda, V., and Malumbres, M. (2009) Cell Cycle Control of Pituitary Development and Disease. J. Mol. Endocrinol. 42, 75-86.

PMID: 18987159




Infante, A., Laresgoiti, U., Fernández-Rueda, J., Fullaondo, A., Galán, J., Díaz-Uriarte, R., Malumbres, M., Field, S.J. and Zubiaga, A.M. (2008) E2F2 Represses Cell Cycle Regulators to Maintain Quiescence. Cell Cycle 7, 3915-3927.

PMID: 19066456


Pérez de Castro I, de Cárcer G, Montoya G, Malumbres M. (2008) Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Curr Opin Pharmacol. 8, 375-383.

PMID: 18644252

García-Higuera, I., Manchado, E., Dubus, P., Cañamero, M., Mendez, J., Moreno, S. and Malumbres, M. (2008) Genomic Stability and Tumor Suppression by the APC/C Cofactor Cdh1. Nat. Cell Biol. 10, 802-811.

News & Views: Skaar, J.R. and Pagano, M. (2008) Cdh1: a master G0/G1 regulator. Nat. Cell Biol. 10, 755-757.

Faculty of 1000 Biology: evaluations for García-Higuera I et al Nat Cell Biol 2008 Jul 10 (7) :802-11.  http://www.f1000biology.com/article/id/1120229/evaluation.

PMID: 18552834



Bueno, M.J., Pérez de Castro, I. and Malumbres, M. (2008) Control of cell proliferation pathways by microRNAs. Cell Cycle 7, 3143-3148.



Bueno, M.J., Pérez de Castro, I., Gómez de Cedrón, M., Santos, J., Calin, G.A., Cigudosa, J.C., Croce, C.M., Fernández-Piqueras, J. and Malumbres, M. (2008) Genetic and Epigenetic Silencing of microRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression. Cancer Cell 13, 496-506.

News & Views: Faber, J., Gregory, R.I. and Armstrong, A.S. (2008) Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell 13, 467-469.

PMID: 18538733

Malumbres, M., Pevarello, P., Barbacid, M. and Bischoff, J.R. (2008) CDK inhibitors in cancer therapy: What is next? Trends Pharmacol Sci. 29, 16-21.

Fast Moving Fronts paper in the field of Pharmacology & Toxicology (2010). http://sciencewatch.com/dr/fmf/2010/10julfmf/10julfmfMalu/

PMID: 18054800




Malumbres, M. (2007) Cyclins and related kinases in cancer cells. J. BUON 12, S45-S52.

PMID: 17935277

Santamaría, D., Barrière, C., Cerqueira, A., Hunt, S.L., Tardy, C., Newton, K., Cáceres, J.F., Dubus, P., Malumbres, M. and Barbacid, M. (2007) Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448, 811-815.

PMID: 17700700

Malumbres, M. (2007) Cyclin-dependent kinases and their regulators as potential targets for anticancer therapeutics. In: Principles of Molecular Oncology, Bronchud, ed. Humana Press, pp. 204-235.


Quereda, V., Martinalbo, J., Dubus, P., Carnero, A. and Malumbres, M. (2007) Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene 26, 7665-7674.

PMID: 17599058

Barrière, C., Santamaría, D., Cerqueira, A., Galán, J., Martín, A., Ortega, S., Malumbres, M., Dubus, P. and Barbacid, M. (2007) Mice thrive without Cdk4 and Cdk2. Mol. Oncol. 1, 72-83.

PMID: 19383288

Cascón, A.,* Escobar, B.,* Montero-Conde, C., Rodríguez-Antona, C., Ruiz-Llorente, S., Osorio, A., Mercadillo, F., Letón, R., de Campos, J.M., García-Sagredo, J.M., Benítez, J., Malumbres, M. and Robledo, M. (2007) Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients. Hum. Mutat. 28, 613-621. [* Co-corresponding authors].

PMID: 17311301

de Cárcer, G.; Pérez de Castro, I. and Malumbres, M. (2007) Targeting cell cycle kinases for cancer therapy. Curr. Med. Chem. 14, 969-985.

PMID: 17439397

Pérez de Castro, I., de Cárcer, G. and Malumbres, M. (2007) A census of mitotic cancer genes. New insights into tumor cell biology and cancer therapy. Carcinogenesis 28, 899-912.

PMID: 17259655

Malumbres, M. and Barbacid, M. (2007) Cell cycle kinases in cancer. Curr. Opin. Genet. Dev. 17, 60-65.

PMID: 17208431




Malumbres, M. (2006) Preclinical models for cell cycle-targeted therapies. Adv. Exp. Med. Biol. 587, 139-147.

PMID: 17163163

Blazquez, C., Carracedo, A., Barrado, L., Real, P.J., Fernández-Luna, J.L., Velasco, G., Malumbres, M. and Guzman, M. (2006) Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J. 20, 2633-2635.

PMID: 17065222


Tormo, D., Ferrer, A., Gaffal, E., Wenzel, J., Basner-Tschakarjan, E., Steitz, J., Heukamp, L.C., Gutgemann, I., Buettner, R., Malumbres, M., Barbacid, M., Merlino, G., Tuting, T. (2006). Rapid Growth of Invasive Metastatic Melanoma in Carcinogen-Treated Hepatocyte Growth Factor/Scatter Factor-Transgenic Mice Carrying an Oncogenic CDK4 Mutation. Am. J. Pathol. 169, 665-672.

PMID: 16877364

Malumbres, M. (2006) Therapeutic opportunities to control tumor cell cycles. Clin. Transl. Oncol. 8, 399-408.

PMID: 16790392

Hacker, E., Muller, H.K., Irwin, N., Gabrielli, B., Lincoln, D., Pavey, S., Powell, M.B., Malumbres, M., Barbacid, M., Hayward, N. and Walker, G. (2006) Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Res. 66, 2946-2952.

PMID: 16540642


Malumbres, M. and Barbacid, M. (2006) Is Cyclin D1/Cdk4 kinase a bona-fide cancer target? Cancer Cell 9, 2-4.

PMID: 16413464


Malumbres, M., Dubus, P. and Ortega, S. (2006) Mouse models to study the in vivo function of Cyclin-dependent kinases in normal homeostasis and tumor development. In: Inhibitors of cyclin-dependent kinases as anti-tumor agents (Smith, P.J. and Yue, E.W., eds.) CRC Press, Boca Raton. pp. 55-83.


Duensing, A., Liu, Y., Tseng, M., Malumbres, M., Barbacid, M. and Duesing, S. (2006) Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene 25, 2943-2949.

PMID: 16331279

Steitz, J., Büchs, S., Tormo, D., Ferrer, A., Wenzel, J., Huber, C., Wölfel, T., Barbacid, M., Malumbres, M. and Tüting, T. (2006) Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin. Int. J. Cancer 118, 373-380.

PMID: 16049960




Barbacid, M., Ortega, S., Sotillo, R., Odajima, J., Martín, A., Santamaría, D., Dubus, P. and Malumbres, M. (2005) Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases. Cold Spring Harb. Symp. Quant. Biol. 70, 233-240.

PMID: 16869759

Malumbres, M. and Barbacid, M. (2005) Mammalian cyclin-dependent kinases. Trends Biochem. Sci., 30, 630-641.

PMID: 16236519

Abella, A., Dubus, P., Malumbres, M., Rane, S.G., Kiyokawa, H., Sicard, A., Vignon, F., Langin, D., Barbacid, M. and Fajas, L. (2005) Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metabolism 2, 239-249.

PMID: 16213226

Martín, A., Odajima, J., Hunt, S.L., Dubus, P., Ortega, S., Malumbres, M.* and Barbacid, M.* (2005) Cell Cycle Inhibition and Tumor Suppression by p21Cip1 and p27Kip1 are Independent of Cdk2. Cancer Cell 7, 591-598. [*Co-corresponding authors]

PMID: 15950907

Sotillo, R., Renner, O., Dubus, P., Ruiz-Cabello, J., Martín-Caballero, J., Barbacid, M., Carnero, A. and Malumbres, M. (2005) Cooperation Between Cdk4 and p27Kip1 in Tumor Development: a Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity. Cancer Res., 65, 3846-3852.

PMID: 15867383

Pérez de Castro I, Benet M, Jiménez M, Alzabin S, Malumbres M, Pellicer A. (2005) Mouse p10, an alternative spliced form of p15INK4b, inhibits cell cycle progression and malignant transformation. Cancer Res., 65, 3249-3256.

PMID: 15833857

Malumbres, M. (2005) Revisiting the “Cdk-centric” view of the mammalian cell cycle. Cell Cycle 4, 206-210.

PMID: 15655365





Auwerx, J., Avner, P., Baldock, R., Ballabio, A., Balling, R., Barbacid, M., Berns, A., Bradley, A., Brown, S., Carmeliet, P., Chambon, P., Cox, R., Davidson, D., Davies,  K., Duboule, D., Forejt, J., Granucci, F., Hastie, N., Hrabé de Angelis, M., Jackson, I., Kioussis, D., Kollias, K., Lathrop, M., Lendahl, U., Malumbres, M., Melchner, H. von, Müller, W., Partanen, J., Ricciardi-Castagnoli, P., Rigby, P., Rosen, B., Rosenthal, N., Skarnes, B., Stewart, A.F., Thornton, J., Tocchini-Valentini, G., Wagner, E., Wahli, W. and Wurst, W. (2004) The European dimension for the mouse genome mutagenesis program. Nat. Genet. 36, 925-927.

PMID: 15340424

Malumbres, M.*, Sotillo, R., Santamaría, D., Galán, J., Cerezo, A., Ortega, S., Dubus, P. and Barbacid, M.* (2004) Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118, 493-504. [*Co-corresponding authors]

PMID: 15315761
Cell Division and Cancer Group

Centro Nacional de Investigaciones Oncológicas (CNIO) Spanish National Cancer Research Centre

Melchor Fernández Almagro 3, E-28029 Madrid, Spain